Monitoring the Remodeling of Biohybrid Tissue-Engineered Vascular Grafts by Multimodal Molecular Imaging.
molecular imaging
poly(lactic-co-glycolic acid)
superparamagnetic iron-oxide nanoparticles
tissue-engineering
αvβ3 integrins
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
13
12
2021
pubmed:
5
2
2022
medline:
8
4
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts' structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron-oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic-co-glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin- and collagen-targeted probes. Finally, molecular US of α
Identifiants
pubmed: 35119216
doi: 10.1002/advs.202105783
pmc: PMC8981893
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2105783Subventions
Organisme : German Research Foundation in the Package Proposals PAK 961
ID : 403039938
Organisme : Deutsche Forschungsgemeinschaft
Informations de copyright
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
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