Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.

Animals Datasets as Topic Diabetes Mellitus, Type 2 / blood Diet, High-Fat Disease Models, Animal Female Gene Knock-In Techniques Gene Knockout Techniques Glucose / metabolism Humans Hyperinsulinism / blood Insulin / blood Insulin Resistance / genetics Insulin-Secreting Cells / metabolism Male Mice Mice, Transgenic RNA-Seq Receptor, Insulin / deficiency Sex Factors

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 02 2022
Historique:
received: 05 04 2021
accepted: 05 01 2022
entrez: 9 2 2022
pubmed: 10 2 2022
medline: 5 3 2022
Statut: epublish

Résumé

Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an Ins1

Identifiants

DOI: 10.1038/s41467-022-28039-8 PMID: 35136059 PMC: PMC8826929
pubmed: 35136059
doi: 10.1038/s41467-022-28039-8
pii: 10.1038/s41467-022-28039-8
pmc: PMC8826929
doi:

Substances chimiques

Insulin 0
Receptor, Insulin EC 2.7.10.1
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

735

Subventions

Organisme : CIHR
ID : 133692
Pays : Canada
Organisme : NIDDK NIH HHS
ID : R01 DK073716
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114686
Pays : United States
Organisme : CIHR
ID : 148451
Pays : Canada
Organisme : NIDDK NIH HHS
ID : U24 DK093000
Pays : United States
Organisme : BLRD VA
ID : I01 BX002728
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Søs Skovsø (S)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Evgeniy Panzhinskiy (E)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Jelena Kolic (J)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0003-4151-1280

Haoning Howard Cen (HH)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0001-8045-1335

Derek A Dionne (DA)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Xiao-Qing Dai (XQ)

Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.

Rohit B Sharma (RB)

Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.

Lynda Elghazi (L)

Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.

Cara E Ellis (CE)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Katharine Faulkner (K)

Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.

Stephanie A M Marcil (SAM)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Peter Overby (P)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Nilou Noursadeghi (N)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Daria Hutchinson (D)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Xiaoke Hu (X)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Hong Li (H)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Honey Modi (H)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Jennifer S Wildi (JS)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

J Diego Botezelli (JD)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Hye Lim Noh (HL)

Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
Charles River Laboratories, Shrewsbury, MA, USA.

Sujin Suk (S)

Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.

Brian Gablaski (B)

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Charles River Laboratories, Shrewsbury, MA, USA.

Austin Bautista (A)

Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.

Ryekjang Kim (R)

Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.

Corentin Cras-Méneur (C)

Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-8921-8927

Stephane Flibotte (S)

UBC Life Sciences Institute Bioinformatics Facility, University of British Columbia, Vancouver, BC, Canada.

Sunita Sinha (S)

UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

Dan S Luciani (DS)

BC Children's Hospital Research Institute, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Corey Nislow (C)

UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0002-4016-8874

Elizabeth J Rideout (EJ)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Eric N Cytrynbaum (EN)

Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0001-8789-1667

Jason K Kim (JK)

Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
ORCID: 0000-0002-7185-042X

Ernesto Bernal-Mizrachi (E)

Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine and Miami VA Health Care System, Miami, FL, USA.

Laura C Alonso (LC)

Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0001-5056-8970

Patrick E MacDonald (PE)

Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.

James D Johnson (JD)

Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada. James.d.johnson@ubc.ca.
ORCID: 0000-0002-7523-9433

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Jeux de données comme sujet › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-in de gènes › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperinsulinisme › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteur à l'insuline › Beta-cell specific Insr deletion promotes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Beta-cell specific Insr deletion promotes...