Deciphering binding affinity, energetics, and base specificity of plant alkaloid Harmane with AT and GC hairpin duplex DNA.
GC base specificity
Harmane
duplex DNA
molecular docking
spectroscopy
Journal
Luminescence : the journal of biological and chemical luminescence
ISSN: 1522-7243
Titre abrégé: Luminescence
Pays: England
ID NLM: 100889025
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
01
02
2022
received:
08
12
2021
accepted:
08
02
2022
pubmed:
15
2
2022
medline:
4
5
2022
entrez:
14
2
2022
Statut:
ppublish
Résumé
Insights into binding efficacy and thermodynamic aspects of small molecules are important for rational drug designing and development. Here, the interaction of Harmane (Har), a very important bioactive indole alkaloid, with AT and GC hairpin duplex-DNAs has been reported using various biophysical tools. Detailed molecular mechanism with special emphasis on binding nature, base specificity, and thermodynamics have been elucidated via probing nucleic acids with varying base compositions. Har bound to both the DNA strands exhibited hypochromic effect in absorbance whereas bathochromic and hypochromic effects in fluorescence spectra. The binding constants estimated were in the order of 10
Substances chimiques
Alkaloids
0
Harmine
4FHH5G48T7
harman
82D6J0535P
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
691-701Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology
ID : BT/PR25026/NER/95/963/2017
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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