mTOR signaling cascade: novel clinical implications in HLA and non-HLA antibody-mediated vasculopathies?

Antibodies Graft Rejection / immunology HLA Antigens / immunology Signal Transduction TOR Serine-Threonine Kinases / metabolism

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
03 2022
Historique:
received: 13 10 2021
revised: 27 11 2021
accepted: 07 12 2021
entrez: 22 2 2022
pubmed: 23 2 2022
medline: 12 3 2022
Statut: ppublish

Résumé

Antibodies targeting endothelial antigens represent major threats to the integrity of endothelial vasculature, contributing to development of organ transplant rejection and vasculopathies. In this issue, Catar et al. present the mechanisms by which non-human leukocyte antigen angiotensin II type 1 receptor and endothelin-1 type A receptor antibodies mediate impairment of endothelial repair via β2-arrestin link to the mammalian target of rapamycin pathway. This commentary discusses the mechanisms of human leukocyte antigen and non-human leukocyte antigen antibody-endothelium interactions, and the clinical implications and challenges of the use of mammalian target of rapamycin signaling activation as biomarker and therapeutic target in vasculopathies.

Identifiants

DOI: 10.1016/j.kint.2021.12.008 PMID: 35190030
pubmed: 35190030
pii: S0085-2538(21)01167-4
doi: 10.1016/j.kint.2021.12.008
pii:
doi:

Substances chimiques

Antibodies 0
HLA Antigens 0
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

451-454

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Auteurs

Kevin Louis (K)

Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unite de Mixte Recherche S970, Université de Paris, Paris, France; Kidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Alexandre Loupy (A)

Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unite de Mixte Recherche S970, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: alexandreloupy@gmail.com.

Carmen Lefaucheur (C)

Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unite de Mixte Recherche S970, Université de Paris, Paris, France; Kidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: carmen.lefaucheur@wanadoo.fr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › mTOR signaling cascade: novel clinical...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › mTOR signaling cascade: novel clinical...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › mTOR signaling cascade: novel clinical...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › mTOR signaling cascade: novel clinical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › mTOR signaling cascade: novel clinical...