Multiple early factors anticipate post-acute COVID-19 sequelae.

Adaptive Immunity / genetics Adolescent Adult Aged Aged, 80 and over Autoantibodies / blood Biomarkers / metabolism Blood Proteins / metabolism CD8-Positive T-Lymphocytes / immunology COVID-19 / complications Convalescence Disease Progression Female Humans Immunity, Innate / genetics Longitudinal Studies Male Middle Aged Risk Factors SARS-CoV-2 / isolation & purification Transcriptome Young Adult Post-Acute COVID-19 Syndrome
COVID-19 PASC RNAemia antibodies auto-antibodies computational biology immune system immunology long COVID metabolomics multi-omics proteomics single cell single-cell CITE-seq single-cell RNA-seq single-cell TCR-seq single-cell secretome symptoms transcriptome viremia

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
03 03 2022
Historique:
received: 29 09 2021
revised: 14 12 2021
accepted: 19 01 2022
pubmed: 27 2 2022
medline: 18 3 2022
entrez: 26 2 2022
Statut: ppublish

Résumé

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8

Identifiants

DOI: 10.1016/j.cell.2022.01.014 PMID: 35216672 PMC: PMC8786632
pubmed: 35216672
pii: S0092-8674(22)00072-1
doi: 10.1016/j.cell.2022.01.014
pmc: PMC8786632
pii:
doi:

Substances chimiques

Autoantibodies 0
Biomarkers 0
Blood Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

881-895.e20

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007290
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI138258
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040395
Pays : United States
Organisme : NCATS NIH HHS
ID : UG3 TR002884
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI068129
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI153559
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI155685
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007044
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057229
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128914
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI163131
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests J.R.H. and A.R. are founders and board members of PACT Pharma. J.R.H. is a board member of Isoplexis, and A.R. is the scientific advisor to Isoplexis. M.M.D. is a member of the Scientific Advisory Board of PACT Pharma. J.A.B. is a member of the Scientific Advisory Boards of Arcus, Solid, and VIR. J.A.B. is a member of the Board of Directors of Gilead and Provention. J.A.B. is the CEO of Sonoma Biotherapeutics. L.L.L. is on the scientific advisory boards of Alector, Atreca, Dragonfly, DrenBio, Nkarta, Obsidian Therapeutics, and SBI Biotech. R.G. has received consulting income from Juno Therapeutics, Takeda, Infotech Soft, Celgene, and Merck, has received research support from Janssen Pharmaceuticals and Juno Therapeutics, and declares ownership in CellSpace Biosciences. P.D.G. is on the Scientific Advisory Board of Celsius, Earli, Elpiscience, Immunoscape, Rapt, and Nextech, was a scientific founder of Juno Therapeutics, and receives research support from Lonza. J.D.G. declared contracted research with Gilead, Lilly, and Regeneron. J.A.H. received consulting fees or honoraria from Gilead Sciences, Amplyx, Allovir, Allogene therapeutics, CRISPR therapeutics, CSL Behring, OptumHealth, Octapharma, and Takeda and research funding from Takeda, Allovir, Karius, and Gilead Sciences. Q.D., D.H.M., R.T., R.M.G., M.K., and T.M.S. have employment and equity ownership with Adaptive Biotechnologies. The remaining authors declare no competing interests.

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Auteurs

Yapeng Su (Y)

Institute for Systems Biology, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: suyapeng.tju@gmail.com.

Dan Yuan (D)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.

Daniel G Chen (DG)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA 98195, USA.

Rachel H Ng (RH)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.

Kai Wang (K)

Institute for Systems Biology, Seattle, WA 98109, USA.

Jongchan Choi (J)

Institute for Systems Biology, Seattle, WA 98109, USA.

Sarah Li (S)

Institute for Systems Biology, Seattle, WA 98109, USA.

Sunga Hong (S)

Institute for Systems Biology, Seattle, WA 98109, USA.

Rongyu Zhang (R)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.

Jingyi Xie (J)

Institute for Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA.

Sergey A Kornilov (SA)

Institute for Systems Biology, Seattle, WA 98109, USA.

Kelsey Scherler (K)

Institute for Systems Biology, Seattle, WA 98109, USA.

Ana Jimena Pavlovitch-Bedzyk (AJ)

Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

Shen Dong (S)

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Christopher Lausted (C)

Institute for Systems Biology, Seattle, WA 98109, USA.

Inyoul Lee (I)

Institute for Systems Biology, Seattle, WA 98109, USA.

Shannon Fallen (S)

Institute for Systems Biology, Seattle, WA 98109, USA.

Chengzhen L Dai (CL)

Institute for Systems Biology, Seattle, WA 98109, USA.

Priyanka Baloni (P)

Institute for Systems Biology, Seattle, WA 98109, USA.

Brett Smith (B)

Institute for Systems Biology, Seattle, WA 98109, USA.

Venkata R Duvvuri (VR)

Institute for Systems Biology, Seattle, WA 98109, USA.

Kristin G Anderson (KG)

Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA.

Jing Li (J)

Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

Fan Yang (F)

Department of Pathology, Stanford University, Stanford, CA 94304, USA.

Caroline J Duncombe (CJ)

Division of Global Health, University of Washington, Seattle, WA 98105, USA.

Denise J McCulloch (DJ)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

Clifford Rostomily (C)

Institute for Systems Biology, Seattle, WA 98109, USA.

Pamela Troisch (P)

Institute for Systems Biology, Seattle, WA 98109, USA.

Jing Zhou (J)

Isoplexis Corporation, Branford, CT 06405, USA.

Sean Mackay (S)

Isoplexis Corporation, Branford, CT 06405, USA.

Quinn DeGottardi (Q)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Damon H May (DH)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Ruth Taniguchi (R)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Rachel M Gittelman (RM)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Mark Klinger (M)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Thomas M Snyder (TM)

Adaptive Biotechnologies, Seattle, WA 98109, USA.

Ryan Roper (R)

Institute for Systems Biology, Seattle, WA 98109, USA.

Gladys Wojciechowska (G)

Institute for Systems Biology, Seattle, WA 98109, USA; Medical University of Białystok, Białystok 15089, Poland.

Kim Murray (K)

Institute for Systems Biology, Seattle, WA 98109, USA.

Rick Edmark (R)

Institute for Systems Biology, Seattle, WA 98109, USA.

Simon Evans (S)

Institute for Systems Biology, Seattle, WA 98109, USA.

Lesley Jones (L)

Institute for Systems Biology, Seattle, WA 98109, USA.

Yong Zhou (Y)

Institute for Systems Biology, Seattle, WA 98109, USA.

Lee Rowen (L)

Institute for Systems Biology, Seattle, WA 98109, USA.

Rachel Liu (R)

Institute for Systems Biology, Seattle, WA 98109, USA.

William Chour (W)

Institute for Systems Biology, Seattle, WA 98109, USA.

Heather A Algren (HA)

Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.

William R Berrington (WR)

Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.

Julie A Wallick (JA)

Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.

Rebecca A Cochran (RA)

Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.

Mary E Micikas (ME)

Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Institute for Systems Biology, Seattle, WA 98109, USA.

Terri Wrin (T)

Monogram Biosciences, South San Francisco, CA 94080, USA.

Christos J Petropoulos (CJ)

Monogram Biosciences, South San Francisco, CA 94080, USA.

Hunter R Cole (HR)

St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

Trevan D Fischer (TD)

St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

Wei Wei (W)

Institute for Systems Biology, Seattle, WA 98109, USA.

Dave S B Hoon (DSB)

St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

Nathan D Price (ND)

Institute for Systems Biology, Seattle, WA 98109, USA.

Naeha Subramanian (N)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Global Heath and Department of Immunology, University of Washington, Seattle, WA 98109, USA.

Joshua A Hill (JA)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

Jennifer Hadlock (J)

Institute for Systems Biology, Seattle, WA 98109, USA.

Andrew T Magis (AT)

Institute for Systems Biology, Seattle, WA 98109, USA.

Antoni Ribas (A)

Department of Medicine, University of California, Los Angeles, and Parker Institute for Cancer Immunotherapy, Los Angeles, CA 90095, USA.

Lewis L Lanier (LL)

Department of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.

Scott D Boyd (SD)

Department of Pathology, Stanford University, Stanford, CA 94304, USA.

Jeffrey A Bluestone (JA)

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Helen Chu (H)

Division of Global Health, University of Washington, Seattle, WA 98105, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

Leroy Hood (L)

Institute for Systems Biology, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.

Raphael Gottardo (R)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Statistics, University of Washington, Seattle, WA 98195, USA; Biomedical Data Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland.

Philip D Greenberg (PD)

Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA.

Mark M Davis (MM)

Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Jason D Goldman (JD)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. Electronic address: jason.goldman@swedish.org.

James R Heath (JR)

Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Multiple early factors anticipate post-acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Convalescence › Multiple early factors anticipate post-acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Multiple early factors anticipate post-acute...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Multiple early factors anticipate post-acute...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Troubles post-infectieux › Syndrome de post-COVID-19 › Multiple early factors anticipate post-acute...