HLA-disease association and pleiotropy landscape in over 235,000 Finns.
Biobank
Disease susceptibility
HLA
Pleiotropy
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
14
10
2021
revised:
31
01
2022
accepted:
09
02
2022
pubmed:
1
3
2022
medline:
27
4
2022
entrez:
28
2
2022
Statut:
ppublish
Résumé
The human leukocyte antigen (HLA) system is the single most important genetic susceptibility factor for many autoimmune diseases and immunological traits. For systematic population-level analysis of HLA-phenotype association landscape we imputed the alleles of classical HLA genes in a discovery cohort of 146,630 and replication cohort of 89,340 Finns of whom SNP genotype data and 3,355 disease phenotypes were available as part of the FinnGen project. In total, 3,649 statistically significant single HLA allele associations in 368 phenotypes were found. Known susceptibility associations clearly dominated the landscape but we discovered also a few previously poorly established HLA associations such as DQA1*01:03 and DQB1*06:03 with mental and behavioural disorders due to cannabinoids (p-value = 10
Identifiants
pubmed: 35221124
pii: S0198-8859(22)00035-0
doi: 10.1016/j.humimm.2022.02.003
pii:
doi:
Substances chimiques
HLA-DQ alpha-Chains
0
HLA-DQ beta-Chains
0
HLA-DRB1 Chains
0
Histocompatibility Antigens Class I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-398Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.