ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.

ATP Citrate (pro-S)-Lyase / genetics Bone Marrow Endothelial Protein C Receptor / metabolism Hematopoietic Stem Cells / physiology Histones / metabolism
Acly bone marrow regeneration hematopoietic stem cells mitochondrial metabolism

Journal

The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664

Informations de publication

Date de publication:
19 04 2022
Historique:
revised: 21 01 2022
received: 16 08 2021
accepted: 25 01 2022
pubmed: 2 3 2022
medline: 21 4 2022
entrez: 1 3 2022
Statut: ppublish

Résumé

In order to support bone marrow regeneration after myeloablation, hematopoietic stem cells (HSCs) actively divide to provide both stem and progenitor cells. However, the mechanisms regulating HSC function and cell fate choice during hematopoietic recovery remain unclear. We herein provide novel insights into HSC regulation during regeneration by focusing on mitochondrial metabolism and ATP citrate lyase (ACLY). After 5-fluorouracil-induced myeloablation, HSCs highly expressing endothelial protein C receptor (EPCR

Identifiants

DOI: 10.15252/embj.2021109463 PMID: 35229328 PMC: PMC9016348
pubmed: 35229328
doi: 10.15252/embj.2021109463
pmc: PMC9016348
doi:

Substances chimiques

Endothelial Protein C Receptor 0
Histones 0
ATP Citrate (pro-S)-Lyase EC 2.3.3.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e109463

Informations de copyright

© 2022 The Authors.

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Auteurs

Terumasa Umemoto (T)

Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0003-0423-9003

Alban Johansson (A)

Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0001-8171-0319

Shah Adil Ishtiyaq Ahmad (SAI)

Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0002-9656-7671

Michihiro Hashimoto (M)

Laboratory of Stem Cell Regulation, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0003-1673-3340

Sho Kubota (S)

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0001-6119-1259

Kenta Kikuchi (K)

Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0002-6084-7559

Haruki Odaka (H)

Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

Takumi Era (T)

Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

Daisuke Kurotaki (D)

Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Goro Sashida (G)

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0003-2318-5987

Toshio Suda (T)

Laboratory of Stem Cell Regulation, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.
ORCID: 0000-0001-7540-1771

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › ATP citrate (pro-S)-lyase › ATP citrate lyase controls hematopoietic stem...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › ATP citrate lyase controls hematopoietic stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteur endothélial de la protéine C › ATP citrate lyase controls hematopoietic stem...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › ATP citrate lyase controls hematopoietic stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › ATP citrate lyase controls hematopoietic stem...