HrgS (Avin_34990), a novel histidine-kinase related to GacS, regulates alginate synthesis in Azotobacter vinelandii.
Azotobacter
algD
Alginate
GacA
GacS
RsmZ
Journal
FEMS microbiology letters
ISSN: 1574-6968
Titre abrégé: FEMS Microbiol Lett
Pays: England
ID NLM: 7705721
Informations de publication
Date de publication:
24 02 2022
24 02 2022
Historique:
received:
15
08
2021
revised:
31
01
2022
accepted:
08
03
2022
pubmed:
11
3
2022
medline:
6
5
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
Azotobacter vinelandii is a soil bacterium that produces alginates, a family of polymers of biotechnological interest. In A. vinelandii, alginate production is controlled by the two-component system GacS/GacA. GacS/GacA, in turn, regulates the Rsm post-transcriptional regulatory system establishing a cascade that regulates alginate biosynthesis by controlling the expression of the algD biosynthetic gene. In Pseudomonas aeruginosa, GacS/GacA is influenced by other histidine-kinases constituting a multicomponent signal transduction system. In this study, we explore the presence of GacS-related histidine-kinases in A. vinelandii and discover a novel histidine-kinase (Avin_34990, renamed HrgS). This histidin-kinase acts as a negative regulator of alginate synthesis by controlling the transcription of the sRNAs belonging to the Rsm post-transcriptional regulatory system, for which a functional GacS is required.
Identifiants
pubmed: 35266527
pii: 6546211
doi: 10.1093/femsle/fnac024
pii:
doi:
Substances chimiques
Alginates
0
Bacterial Proteins
0
Histidine
4QD397987E
Histidine Kinase
EC 2.7.13.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.