Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity.
KIT mutations
PDGFRA mutations
chromosome aberrations
gastrointestinal stromal tumor
intratumor heterogeneity
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
12
2021
accepted:
17
02
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm with variable behavior. An increased understanding of the tumor pathogenesis may improve clinical decision-making. Our aim was to obtain more data about the overall chromosome aberrations and intratumor cytogenetic heterogeneity in GIST. We analyzed 306 GIST samples from 291 patients using G-banding, direct sequencing, and statistics. Clonal chromosome aberrations were found in 81% of samples, with 34% of 226 primary tumors demonstrating extensive cytogenetic heterogeneity. 135 tumors had simple (≤5 changes) and 91 had complex (>5 changes) karyotypes. The karyotypically complex tumors more often were non-gastric (
Identifiants
pubmed: 35284037
doi: 10.18632/oncotarget.28209
pii: 28209
pmc: PMC8901076
doi:
Substances chimiques
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Receptor, Platelet-Derived Growth Factor alpha
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
508-517Informations de copyright
Copyright: © 2022 Gorunova et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
Références
J Pathol. 2007 Mar;211(4):463-70
pubmed: 17226762
Genes Chromosomes Cancer. 2007 Mar;46(3):261-76
pubmed: 17171690
Lab Invest. 2004 Jul;84(7):874-83
pubmed: 15146165
BMC Med. 2010 May 14;8:26
pubmed: 20470368
Cancer Genet Cytogenet. 1998 Apr 15;102(2):135-8
pubmed: 9546066
Genome Res. 2002 Jun;12(6):996-1006
pubmed: 12045153
Arch Pathol Lab Med. 2006 Oct;130(10):1466-78
pubmed: 17090188
Adv Anat Pathol. 2017 Sep;24(5):259-267
pubmed: 28632504
Hematol Oncol Clin North Am. 2013 Oct;27(5):871-88
pubmed: 24093165
Cancer Genet Cytogenet. 2002 Oct 1;138(1):1-10
pubmed: 12419577
Lab Invest. 2010 Sep;90(9):1285-94
pubmed: 20548289
Hum Pathol. 2002 Mar;33(3):316-21
pubmed: 11979372
Science. 1998 Jan 23;279(5350):577-80
pubmed: 9438854
Virchows Arch. 2010 Feb;456(2):111-27
pubmed: 20165865
J Pathol. 2004 Apr;202(4):421-9
pubmed: 15095269
Hum Pathol. 2014 Jan;45(1):85-97
pubmed: 24157063
Cancer Res. 2000 Jul 15;60(14):3899-903
pubmed: 10919666
Int J Mol Sci. 2020 May 07;21(9):
pubmed: 32392832
Cancer Genet Cytogenet. 2001 Jul 1;128(1):24-30
pubmed: 11454425
Ann Surg Oncol. 2021 Oct;28(11):6837-6845
pubmed: 33651216
Am J Pathol. 2004 Jul;165(1):107-13
pubmed: 15215166
Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):563-569
pubmed: 32859634
J Formos Med Assoc. 2009 Jan;108(1):28-37
pubmed: 19181605
Genes Chromosomes Cancer. 2007 Jun;46(6):564-76
pubmed: 17330260
Genes Chromosomes Cancer. 2009 Oct;48(10):886-96
pubmed: 19585585
Br J Surg. 2018 Jan;105(2):e169-e175
pubmed: 29341147
Radiographics. 2013 Oct;33(6):1673-90
pubmed: 24108557
Front Oncol. 2020 Apr 22;10:504
pubmed: 32391261
Pathobiology. 2020;87(3):171-178
pubmed: 32079019