Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase.
Alkyl (Hetero)Aryl Ketones
Amine Dehydrogenase
Asymmetric Reductive Amination
Chiral Amines
Directed Evolution
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
16 05 2022
16 05 2022
Historique:
received:
10
02
2022
pubmed:
15
3
2022
medline:
11
5
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
The direct asymmetric reductive amination of heteroaryl ketones has been a long-standing synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) from Jeotgalicoccus aerolatus for the asymmetric synthesis of chiral α-(hetero)aryl primary amines in excellent conversions (up to 99 %) and enantioselectivities (up to 99 % ee). The best AmDH variant (Ja-AmDH-M3
Identifiants
pubmed: 35285128
doi: 10.1002/anie.202202264
doi:
Substances chimiques
Amines
0
Ketones
0
Oxidoreductases
EC 1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202202264Informations de copyright
© 2022 Wiley-VCH GmbH.
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