Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
12
2021
accepted:
01
02
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Power laws are of interest to several scientific disciplines because they can provide important information about the underlying dynamics (e.g. scale invariance and self-similarity) of a given system. Because power laws are of increasing interest to the cardiac sciences as potential indicators of cardiac dysfunction, it is essential that rigorous, standardized analytical methods are employed in the evaluation of power laws. This study compares the methods currently used in the fields of condensed matter physics, geoscience, neuroscience, and cardiology in order to provide a robust analytical framework for evaluating power laws in stem cell-derived cardiomyocyte cultures. One potential power law-obeying phenomenon observed in these cultures is pacemaker translocations, or the spatial and temporal instability of the pacemaker region, in a 2D cell culture. Power law analysis of translocation data was performed using increasingly rigorous methods in order to illustrate how differences in analytical robustness can result in misleading power law interpretations. Non-robust methods concluded that pacemaker translocations adhere to a power law while robust methods convincingly demonstrated that they obey a doubly truncated power law. The results of this study highlight the importance of employing comprehensive methods during power law analysis of cardiomyocyte cultures.
Identifiants
pubmed: 35286321
doi: 10.1371/journal.pone.0263976
pii: PONE-D-21-40812
pmc: PMC8920264
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0263976Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142801
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR065972
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL124503
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Ann Intern Med. 1968 Mar;68(3):591-7
pubmed: 5643681
Sci Rep. 2017 Oct 12;7(1):13020
pubmed: 29026142
Elife. 2015 Jul 07;4:e07224
pubmed: 26151674
Front Physiol. 2018 Feb 07;9:80
pubmed: 29467678
Front Physiol. 2016 Jun 27;7:250
pubmed: 27445842
Front Syst Neurosci. 2014 Sep 23;8:166
pubmed: 25294989
Phys Rev E. 2018 Feb;97(2-1):022134
pubmed: 29548208
Neuron. 2019 Nov 20;104(4):655-664.e4
pubmed: 31601510
Sci Rep. 2013 Nov 14;3:3222
pubmed: 24226045
Nat Rev Cardiol. 2020 Jun;17(6):341-359
pubmed: 32015528
Circ Res. 2017 Feb 17;120(4):627-629
pubmed: 28209795
Phys Rev Lett. 2005 Feb 11;94(5):058101
pubmed: 15783702
Heart Rhythm. 2014 Jul;11(7):1220-1
pubmed: 24727583
Front Physiol. 2020 Mar 10;11:175
pubmed: 32210835
Nat Commun. 2021 May 26;12(1):3155
pubmed: 34039977
Clin Physiol. 2001 May;21(3):273-81
pubmed: 11380525
Biosens Bioelectron. 2020 Oct 15;166:112399
pubmed: 32692665
Nat Commun. 2021 Oct 15;12(1):6035
pubmed: 34654800
PLoS One. 2017 Feb 28;12(2):e0170920
pubmed: 28245249
Mol Cell Biol. 2007 Mar;27(5):1649-64
pubmed: 17189427
Circ Res. 2020 Apr 10;126(8):1086-1106
pubmed: 32271675
Biochim Biophys Acta. 2006 Feb;1762(2):232-40
pubmed: 16242921
Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2026-2037
pubmed: 28860223
Ann Noninvasive Electrocardiol. 2020 Jan;25(1):e12681
pubmed: 31475425
Sci Rep. 2020 Sep 30;10(1):16163
pubmed: 32999360
Circ Res. 2017 Jun 9;120(12):1874-1888
pubmed: 28356340
PLoS One. 2014 Jan 29;9(1):e85777
pubmed: 24489671
Sci Rep. 2019 Oct 23;9(1):15174
pubmed: 31645588
Circulation. 1998 May 26;97(20):2031-6
pubmed: 9610533
Nat Protoc. 2017 Jun;12(6):1177-1197
pubmed: 28492526
Phys Rev Lett. 2004 Oct 22;93(17):178103
pubmed: 15525130
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1996 Jan;53(1):414-443
pubmed: 9964272
Cardiovasc Drugs Ther. 1988 Mar;1(6):573-97
pubmed: 3154325
Biophys J. 2006 Oct 1;91(7):2543-51
pubmed: 16844752
J Interv Card Electrophysiol. 1998 Jun;2(2):121-35
pubmed: 9870004
Front Physiol. 2012 Jun 07;3:163
pubmed: 22701101
Circ Res. 2009 Feb 13;104(3):388-97
pubmed: 19096026
Circulation. 1996 Jun 15;93(12):2142-51
pubmed: 8925583
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4447-52
pubmed: 15070738
Front Physiol. 2021 Jul 16;12:712666
pubmed: 34335313
J Cardiovasc Dev Dis. 2017 Apr 27;4(2):
pubmed: 29367536
Sci Rep. 2018 Jan 31;8(1):1967
pubmed: 29386623
Phys Rev Lett. 2011 Aug 12;107(7):078103
pubmed: 21902433
Circulation. 2012 Feb 21;125(7):883-93
pubmed: 22261196
Sci Rep. 2017 Mar 07;7:43210
pubmed: 28266620
Front Cell Dev Biol. 2017 May 05;5:50
pubmed: 28529939
Neuroscientist. 2013 Feb;19(1):88-100
pubmed: 22627091
J Physiol. 2020 Jul;598(14):2941-2956
pubmed: 30571853
Cell Rep. 2012 Nov 29;2(5):1448-60
pubmed: 23103164
Biosystems. 2010 Aug;101(2):144-7
pubmed: 20541587
Dev Biol. 2012 Mar 1;363(1):234-46
pubmed: 22226977
Prog Neurobiol. 2017 Nov;158:132-152
pubmed: 28734836
J Clin Invest. 2005 Dec;115(12):3527-35
pubmed: 16284648
Phys Rev E. 2021 Jan;103(1):L010102
pubmed: 33601642
Stem Cells. 2016 Aug;34(8):2008-15
pubmed: 27250776
Cell Mol Life Sci. 2012 Aug;69(16):2635-56
pubmed: 22388688
Physiol Rev. 2008 Jul;88(3):919-82
pubmed: 18626064
Front Cell Dev Biol. 2020 Mar 19;8:178
pubmed: 32266260
Biophys J. 2012 Jun 6;102(11):2433-42
pubmed: 22713558
J Neurosci. 2003 Dec 3;23(35):11167-77
pubmed: 14657176
Stem Cell Reports. 2014 Nov 11;3(5):804-16
pubmed: 25418725
Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57
pubmed: 22645348
Elife. 2017 Dec 12;6:
pubmed: 29231167
Biol Rev Camb Philos Soc. 2001 May;76(2):161-209
pubmed: 11396846
Sci Rep. 2016 Apr 20;6:24690
pubmed: 27094323