Ribonucleotide Incorporation by Eukaryotic B-Family Replicases and Its Implications for Genome Stability.
DNA polymerase
DNA repair
genome stability
mutagenesis
ribonucleotide
Journal
Annual review of biochemistry
ISSN: 1545-4509
Titre abrégé: Annu Rev Biochem
Pays: United States
ID NLM: 2985150R
Informations de publication
Date de publication:
21 06 2022
21 06 2022
Historique:
pubmed:
16
3
2022
medline:
24
6
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease.
Identifiants
pubmed: 35287470
doi: 10.1146/annurev-biochem-032620-110354
pmc: PMC9384702
mid: NIHMS1827757
doi:
Substances chimiques
Ribonucleotides
0
DNA
9007-49-2
Nucleotidyltransferases
EC 2.7.7.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-155Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES065070
Pays : United States
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