The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.
Hereditary hemochromatosis
Iron absorption
Polyphenols
Reducing dietary iron absorption
Supplement
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
28
10
2021
accepted:
04
02
2022
pubmed:
24
3
2022
medline:
12
8
2022
entrez:
23
3
2022
Statut:
ppublish
Résumé
We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into erythrocytes. Black tea powder, cocoa powder and grape juice extract most effectively precipitated iron in vitro. A PPS mixture of these three extracts precipitated ~ 80% of iron when 2 g was added to a 500 g iron solution containing 20 µg Fe/g. In the iron absorption study, the PPS reduced FIA by ~ 40%: FIA from the meal consumed with the PPS was lower (3.01% (1.60, 5.64)) than with placebo (5.21% (3.92, 6.92)) (p = 0.026)), and FIA from the test drink with the PPS was lower (10.3% (7.29 14.6)) than with placebo (16.9% (12.8 22.2)) (p = 0.002). Our results indicate that when taken with meals, this natural PPS can decrease dietary iron absorption, and might thereby reduce body iron accumulation and the frequency of phlebotomy in patients with HH. clinicaltrials.gov (registration date: 9.6.2019, NCT03990181).
Identifiants
pubmed: 35320401
doi: 10.1007/s00394-022-02829-8
pii: 10.1007/s00394-022-02829-8
pmc: PMC9363374
doi:
Substances chimiques
Hemochromatosis Protein
0
Histocompatibility Antigens Class I
0
Iron, Dietary
0
Polyphenols
0
Powders
0
Tea
0
Iron
E1UOL152H7
Banques de données
ClinicalTrials.gov
['NCT03990181']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2967-2977Informations de copyright
© 2022. The Author(s).
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