Mode of interaction of altretamine with calf thymus DNA: biophysical insights.
Altretamine
binding thermodynamics
calf thymus DNA
groove binding
molecular docking
spectroscopy
viscosity
Journal
Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
medline:
11
5
2023
pubmed:
29
3
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
Insights into drug-DNA interactions have importance in medicinal chemistry as it has a major role in the evolution of new therapeutic drugs. Therefore, binding studies of small molecules with DNA are of significant interest. Spectroscopy, coupled with measurements of viscosity and molecular docking studies were employed to obtain mechanistic insights into the binding of altretamine with calf thymus DNA (CT-DNA). The UV-visible spectroscopic measurements study confirmed altretamine-CT-DNA complex formation with affinity constant ([15.68 ± 0.04] × 10
Identifiants
pubmed: 35343872
doi: 10.1080/07391102.2022.2054472
doi:
Substances chimiques
calf thymus DNA
91080-16-9
Altretamine
Q8BIH59O7H
DNA
9007-49-2
Ethidium
EN464416SI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM