NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24.


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 04 2022
Historique:
pubmed: 1 4 2022
medline: 16 4 2022
entrez: 31 3 2022
Statut: ppublish

Résumé

Structure-based drug discovery (SBDD) largely relies on structural information from X-ray crystallography because traditional NMR structure calculation methods are too time consuming to be aligned with typical drug discovery timelines. The recently developed NMR molecular replacement (

Identifiants

pubmed: 35357834
doi: 10.1021/acs.jmedchem.1c01703
pmc: PMC9017284
doi:

Substances chimiques

Nuclear Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5565-5574

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Auteurs

Felix Torres (F)

Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Eidgenossische Technische Hochschule Zurich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.

Reto Walser (R)

BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom.

Janina Kaderli (J)

Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Eidgenossische Technische Hochschule Zurich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.

Emanuele Rossi (E)

Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Eidgenossische Technische Hochschule Zurich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.

Romel Bobby (R)

BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom.

Martin J Packer (MJ)

Oncology R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom.

Sunil Sarda (S)

BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom.

Graeme Walker (G)

Drug Discovery Unit, Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, United Kingdom.

James R Hitchin (JR)

Drug Discovery Unit, Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, United Kingdom.

Alexander G Milbradt (AG)

BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, United Kingdom.

Julien Orts (J)

Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Eidgenossische Technische Hochschule Zurich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland.
Department of Pharmaceutical Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

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Classifications MeSH