Saccharomyces boulardii attenuates lipopolysaccharide-induced anxiety-like behaviors in rats.


Journal

Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130

Informations de publication

Date de publication:
01 05 2022
Historique:
received: 03 01 2022
revised: 10 03 2022
accepted: 26 03 2022
pubmed: 1 4 2022
medline: 19 4 2022
entrez: 31 3 2022
Statut: ppublish

Résumé

Anxiety is the brain's response to dangerous or stressful situations. Exposure to stressors can cause gut microbiota dysbiosis and activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to the secretion of glucocorticoids associated with anxiety. Recent studies have reported that probiotics can attenuate anxiety-like behaviors by modulation of the gut microbiome composition. The present study aimed to investigate the effects of Saccharomyces boulardii (Sb) administration on anxiety-like behaviors induced by lipopolysaccharide (LPS) in rats. The animals were randomly divided into four groups (Control, LPS, Sb + LPS, and Sb). All animals were orally treated with saline or S. boulardii (10

Identifiants

pubmed: 35358641
pii: S0304-3940(22)00157-4
doi: 10.1016/j.neulet.2022.136600
pii:
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0
Lipopolysaccharides 0
Serotonin 333DO1RDJY
Corticosterone W980KJ009P
Hydrocortisone WI4X0X7BPJ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

136600

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Fatemeh Babaei (F)

Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammadreza Mirzababaei (M)

Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Ghazaleh Mohammadi (G)

Department of Molecular Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Leila Dargahi (L)

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Marjan Nassiri-Asl (M)

Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: marjannassiriasl@sbmu.ac.ir.

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Classifications MeSH