Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.

CD8-Positive T-Lymphocytes Cell Differentiation Dendritic Cells Immunotherapy Lymphocyte Count
CD8 T cell exhaustion PD-1 PD-L1 Tpex cDC1 checkpoint chronic LCMV infection dendritic cells immunotherapy scRNA-seq

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
12 04 2022
Historique:
received: 05 07 2021
revised: 20 12 2021
accepted: 10 03 2022
pubmed: 3 4 2022
medline: 16 4 2022
entrez: 2 4 2022
Statut: ppublish

Résumé

Reinvigoration of exhausted CD8

Identifiants

DOI: 10.1016/j.immuni.2022.03.006 PMID: 35366396
pubmed: 35366396
pii: S1074-7613(22)00129-7
doi: 10.1016/j.immuni.2022.03.006
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

656-670.e8

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sabrina Dähling (S)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Ana Maria Mansilla (AM)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg im Breisgau, Germany; Faculty of Biology, Albert Ludwig University, 79104 Freiburg im Breisgau, Germany.

Konrad Knöpper (K)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany.

Anika Grafen (A)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany.

Daniel T Utzschneider (DT)

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Milas Ugur (M)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany.

Paul G Whitney (PG)

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Annabell Bachem (A)

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Panagiota Arampatzi (P)

Core Unit Systems Medicine, University of Würzburg, 97078 Würzburg, Germany.

Fabian Imdahl (F)

Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), 97078 Würzburg, Germany.

Tsuneyasu Kaisho (T)

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, 641-8509 Wakayama, Japan.

Dietmar Zehn (D)

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany.

Frederick Klauschen (F)

Institute of Pathology, Ludwig-Maximilian University of Munich, 81675 Munich, Germany.

Natalio Garbi (N)

Institute of Experimental Immunology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Axel Kallies (A)

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Antoine-Emmanuel Saliba (AE)

Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), 97078 Würzburg, Germany.

Georg Gasteiger (G)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany.

Sammy Bedoui (S)

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Wolfgang Kastenmüller (W)

Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany. Electronic address: wolfgang.kastenmueller@uni-wuerzburg.de.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Type 1 conventional dendritic cells maintain...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Type 1 conventional dendritic cells maintain...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Type 1 conventional dendritic cells maintain...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Type 1 conventional dendritic cells maintain...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Numération des lymphocytes › Type 1 conventional dendritic cells maintain...