Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids.

Alpha-Ketoglutarate-Dependent Dioxygenase FTO Ergot Alkaloids Ferrous Compounds Hydroxylation Molecular Docking Simulation
Aj_EasH Ergot alkaloid Hydroxylases Promiscuity

Journal

Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 02 11 2021
accepted: 19 03 2022
revised: 12 03 2022
pubmed: 8 4 2022
medline: 6 5 2022
entrez: 7 4 2022
Statut: ppublish

Résumé

Ergot alkaloids (EAs) are among the most important bioactive natural products. Fe

Identifiants

DOI: 10.1007/s00253-022-11892-4 PMID: 35389067
pubmed: 35389067
doi: 10.1007/s00253-022-11892-4
pii: 10.1007/s00253-022-11892-4
doi:

Substances chimiques

Ergot Alkaloids 0
Ferrous Compounds 0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO EC 1.14.11.33

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2981-2991

Subventions

Organisme : National Research and Development Program of China
ID : 2019YFA0905100
Organisme : National Research and Development Program of China
ID : 2018YFA0901600
Organisme : the Senior User Project of RV KEXUE, Center for Ocean Mega-Science, CAS
ID : KEXUE2019GZ05
Organisme : National Natural Science Foundation of China
ID : 31872614
Organisme : National Natural Science Foundation of China
ID : 32001036
Organisme : Youth Innovation Promotion Association of the Chinese Academy of Sciences
ID : 2019090
Organisme : Innovative Cross Team project of CAS
ID : JCTD-2019-06

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Références

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Auteurs

Chunyan An (C)

Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Biotechnology College of Tianjin University of Science and Technology, Tianjin, 300457, China. ancy@im.ac.cn.
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China. ancy@im.ac.cn.
ORCID: 0000-0001-9918-5903

Fangfang Zhu (F)

Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Biotechnology College of Tianjin University of Science and Technology, Tianjin, 300457, China.
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Yongpeng Yao (Y)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
ORCID: 0000-0002-6084-1683

Kexin Zhang (K)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

Wei Wang (W)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
ORCID: 0000-0002-4558-4738

Jun Zhang (J)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Guangzheng Wei (G)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

Yue Xia (Y)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Qiang Gao (Q)

Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Biotechnology College of Tianjin University of Science and Technology, Tianjin, 300457, China. gaoqiang@tust.edu.cn.

Shu-Shan Gao (SS)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China. gaoss@im.ac.cn.
ORCID: 0000-0001-6335-2052

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Alpha-ketoglutarate-dependent dioxygenase FTO › Beyond the cyclopropyl ring formation: fungal...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes de l'ergot › Beyond the cyclopropyl ring formation: fungal...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer II › Beyond the cyclopropyl ring formation: fungal...
questionsmedicales.fr › Métabolisme › Hydroxylation › Beyond the cyclopropyl ring formation: fungal...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Beyond the cyclopropyl ring formation: fungal...