The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.

Lactates Memory T Cells Mitochondria / metabolism Mitochondrial Membrane Transport Proteins / metabolism Monocarboxylic Acid Transporters / genetics Pyruvic Acid / metabolism
T cell memory chimeric antigen receptor T cell therapy immunometabolism mitochondrial pyruvate carrier tumor-infiltrating lymphocyte metabolism

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
03 05 2022
Historique:
received: 28 09 2021
revised: 25 01 2022
accepted: 30 03 2022
pubmed: 23 4 2022
medline: 7 5 2022
entrez: 22 4 2022
Statut: ppublish

Résumé

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8

Identifiants

DOI: 10.1016/j.cmet.2022.03.013 PMID: 35452600 PMC: PMC9116152
pubmed: 35452600
pii: S1550-4131(22)00127-9
doi: 10.1016/j.cmet.2022.03.013
pmc: PMC9116152
pii:
doi:

Substances chimiques

Lactates 0
Mitochondrial Membrane Transport Proteins 0
Monocarboxylic Acid Transporters 0
Pyruvic Acid 8558G7RUTR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

731-746.e9

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests M.W. and P.R. are inventors on a patent application related to these findings and have research collaborations with MPC Therapeutics, with P.R. being a member of the advisory board. D.M. is an inventor on patents related to CAR T cell therapy, filed by the University of Pennsylvania and the University of Geneva, and is a consultant for Limula Therapeutics and MPC Therapeutics. P.-C.H. is scientific advisory for Elixiron Immunotherapeutics, Acepodia, and Novartis. P.-C.H. also receives research support from Elixiron Immunotherapeutics. S.Y.L. is a consultant to Senda Biosciences.

Références

FEBS Lett. 1998 May 15;427(3):357-61
pubmed: 9637257
Immunity. 2007 Aug;27(2):281-95
pubmed: 17723218
J Exp Med. 2015 Nov 16;212(12):2041-56
pubmed: 26503446
Mol Cell. 2014 Nov 6;56(3):414-424
pubmed: 25458842
Curr Protoc Mol Biol. 2015 Jan 05;109:21.29.1-21.29.9
pubmed: 25559105
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Nature. 2017 Nov 2;551(7678):115-118
pubmed: 29045397
Mol Cell. 2014 Nov 6;56(3):425-435
pubmed: 25458843
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
J Biol Chem. 2016 Oct 14;291(42):22011-22020
pubmed: 27573239
J Immunother Cancer. 2018 Jul 13;6(1):71
pubmed: 30005714
Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50
pubmed: 25053359
J Clin Invest. 2021 Feb 15;131(4):
pubmed: 33320840
Elife. 2020 Oct 23;9:
pubmed: 33095157
Nat Immunol. 2021 Jun;22(6):746-756
pubmed: 34031618
Anal Chem. 2010 Dec 1;82(23):9818-26
pubmed: 21049934
Nature. 2021 Mar;591(7851):645-651
pubmed: 33589820
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Bioinformatics. 2004 Jun 12;20(9):1453-4
pubmed: 14871861
BMC Res Notes. 2016 Feb 12;9:88
pubmed: 26868221
Bioinformatics. 2011 Apr 1;27(7):1017-8
pubmed: 21330290
Mol Ther. 2009 Aug;17(8):1453-64
pubmed: 19384291
Cell Rep. 2020 Mar 3;30(9):2889-2899.e6
pubmed: 32130894
Methods Mol Biol. 2019;1977:43-70
pubmed: 30980322
Nature. 2012 Jan 04;481(7381):389-93
pubmed: 22217937
Nat Immunol. 2019 Mar;20(3):326-336
pubmed: 30778252
Immunity. 2020 Nov 17;53(5):985-1000.e11
pubmed: 33128876
J Clin Invest. 2021 Aug 16;131(16):
pubmed: 34396987
Nat Biotechnol. 2016 Feb;34(2):184-191
pubmed: 26780180
Nat Rev Cancer. 2012 Oct;12(10):671-84
pubmed: 22996603
Cell. 2021 Mar 4;184(5):1262-1280.e22
pubmed: 33636129
Biotechniques. 2015 Mar 01;58(3):135-9
pubmed: 25757546
Nat Immunol. 2018 Dec;19(12):1366-1378
pubmed: 30420627
BMC Bioinformatics. 2008 Mar 26;9:163
pubmed: 18366760
Immunity. 2016 Dec 20;45(6):1341-1354
pubmed: 27986453
Science. 2002 Sep 20;297(5589):2060-3
pubmed: 12242444
Immunity. 2019 Jan 15;50(1):195-211.e10
pubmed: 30635237
Immunity. 2018 Apr 17;48(4):659-674.e6
pubmed: 29669249
Cancer Discov. 2021 Sep;11(9):2186-2199
pubmed: 33820778
Blood Adv. 2020 Sep 22;4(18):4483-4493
pubmed: 32941648
Bioinformatics. 2004 Nov 22;20(17):3246-8
pubmed: 15180930
Cell Metab. 2016 Nov 8;24(5):657-671
pubmed: 27641098
Immunity. 2017 Apr 18;46(4):596-608
pubmed: 28410989
J Clin Invest. 2008 Dec;118(12):3930-42
pubmed: 19033663
EMBO J. 2006 Sep 6;25(17):3955-65
pubmed: 16917507
Clin Cancer Res. 2011 Aug 15;17(16):5343-52
pubmed: 21737507
Immunity. 2019 May 21;50(5):1202-1217.e7
pubmed: 31027997
Cell. 2015 Sep 10;162(6):1217-28
pubmed: 26321681
Nature. 2018 Jun;558(7709):307-312
pubmed: 29849141
Nat Immunol. 2020 Dec;21(12):1540-1551
pubmed: 33020660
Immunity. 2019 Nov 19;51(5):856-870.e5
pubmed: 31747582
Front Oncol. 2018 May 28;8:174
pubmed: 29892572
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Mol Cell. 2015 Jan 8;57(1):95-107
pubmed: 25482511
Nature. 2020 Sep;585(7824):277-282
pubmed: 32879489
Nat Immunol. 2021 Aug;22(8):996-1007
pubmed: 34282329
Nat Metab. 2020 Aug;2(8):703-716
pubmed: 32747793
Nat Immunol. 2017 May;18(5):573-582
pubmed: 28288100
BMC Bioinformatics. 2010 May 11;11:237
pubmed: 20459804
Nat Commun. 2021 May 20;12(1):2965
pubmed: 34017005
Immunity. 2014 Jul 17;41(1):75-88
pubmed: 25001241
Science. 2012 Jul 6;337(6090):96-100
pubmed: 22628558
Cell Metab. 2015 Oct 6;22(4):669-81
pubmed: 26344103
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Cell. 2015 May 7;161(4):750-61
pubmed: 25957683
Science. 2012 Jul 6;337(6090):93-6
pubmed: 22628554
Biochem J. 1975 Apr;148(1):85-96
pubmed: 1156402
J Clin Invest. 2013 Oct;123(10):4479-88
pubmed: 24091329
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
J Immunol. 2013 Aug 1;191(3):1486-95
pubmed: 23817426
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1659-E1667
pubmed: 28193872
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Cell. 2017 Oct 5;171(2):358-371.e9
pubmed: 28985563
Bioinformatics. 2008 Nov 1;24(21):2534-6
pubmed: 18606607
Bioinformatics. 2012 May 1;28(9):1294-6
pubmed: 22419781

Auteurs

Mathias Wenes (M)

Department of Oncology, University of Lausanne, Épalinges, Switzerland. Electronic address: mathias.wenes@unige.ch.

Alison Jaccard (A)

Department of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.

Tania Wyss (T)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Noelia Maldonado-Pérez (N)

Gene and Cell Therapy Unit, Genomic Medicine Department, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.

Shao Thing Teoh (ST)

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.

Anouk Lepez (A)

Brain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland; Swiss Cancer Center Léman, Geneva and Lausanne, Switzerland.

Fabrice Renaud (F)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Fabien Franco (F)

Department of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.

Patrice Waridel (P)

Protein Analysis Facility, University of Lausanne, Lausanne, Switzerland.

Céline Yacoub Maroun (C)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Benjamin Tschumi (B)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Nina Dumauthioz (N)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Lianjun Zhang (L)

Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China.

Alena Donda (A)

Department of Oncology, University of Lausanne, Épalinges, Switzerland.

Francisco Martín (F)

Gene and Cell Therapy Unit, Genomic Medicine Department, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.

Denis Migliorini (D)

Brain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland; Swiss Cancer Center Léman, Geneva and Lausanne, Switzerland; Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland.

Sophia Y Lunt (SY)

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.

Ping-Chih Ho (PC)

Department of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.

Pedro Romero (P)

Department of Oncology, University of Lausanne, Épalinges, Switzerland. Electronic address: pedro.romero@unil.ch.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › The mitochondrial pyruvate carrier regulates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T mémoire › The mitochondrial pyruvate carrier regulates...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › The mitochondrial pyruvate carrier regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › The mitochondrial pyruvate carrier regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'acides monocarboxyliques › The mitochondrial pyruvate carrier regulates...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Pyruvates › Acide pyruvique › The mitochondrial pyruvate carrier regulates...