Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC-Q/TOF-MS and quantitative analysis of multiple components by a single marker.
Angelica dahurica
Angelica dahurica var. formosana; high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS)
Chemometrics
quantitative analysis of multiple components by a single marker (QAMS)
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
07
04
2022
received:
22
12
2021
accepted:
12
04
2022
pubmed:
27
4
2022
medline:
7
7
2022
entrez:
26
4
2022
Statut:
ppublish
Résumé
Angelica dahurica(BZ) and Angelica dahurica var. formosana(HBZ) are two plant sources of Angelicae dahuricae Radix. Although BZ and HBZ are commonly used herbal medicines with great medicinal and dietary values, study on their phytochemicals and bioactive compositions is limited. To compare the chemical compositions of BZ and HBZ and find the chemical makers for discrimination and quality evaluation of the two botanical origins of Angelicae dahuricae Radix. A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established for chemical profiling of BZ and HBZ. Then, a quantitative analysis of multiple components by a single marker method was developed for simultaneous determination of nine bioactive coumarins (xanthotoxol, oxypeucedanin hydrate, byakangelicin, xanthotoxin, bergapten, oxypeucedanin, phellopterin, imperatorin and isoimperatorin). Moreover, chemometrics were performed to compare and discriminate BZ and HBZ samples. A total of 30 coumarins compounds were identified, and the chemical compositions in BZ and HBZ were quite similar. The quantitative analysis showed that there were significant differences in the contents of bioactive coumarins, and the chemometric analysis indicated five coumarins (xanthotoxol, xanthotoxin, bergapten, phellopterin and isoimperatorin) were responsible for the significant differences between BZ and HBZ, which could be used as chemical markers to distinguish the two original plant sources of Angelicae dahuricae Radix. The present work provided useful information for understanding the chemical differences between BZ and HBZ and also provided feasible methods for quality evaluation and discrimination of herbal medicines originating from multiple botanical sources.
Substances chimiques
Coumarins
0
Drugs, Chinese Herbal
0
5-Methoxypsoralen
4FVK84C92X
Methoxsalen
U4VJ29L7BQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
776-791Subventions
Organisme : Innovation Team of Hebei Province Modern Agricultural Industry Technology System
ID : HBCT2018060205
Organisme : Research Foundation of Hebei Provincial Administration of Traditional Chinese Medicine
ID : 2022100
Organisme : Research Foundation of Hebei Provincial Administration of Traditional Chinese Medicine
ID : Z2022019
Organisme : Research Foundation of Hebei Province Education Department
ID : BJ2019006
Organisme : Natural Science Foundation of Hebei Province
ID : H2021423004
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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