ABCB1 gene polymorphisms impact the effect of high-dose intravenous methylprednisolone therapy on optic neuritis associated with AQP4-IgG-positive neuromyelitis optica spectrum disorder.
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Aquaporin 4
/ immunology
Autoantibodies
/ metabolism
Glucocorticoids
/ therapeutic use
Humans
Immunoglobulin G
Methylprednisolone
/ therapeutic use
Multiple Sclerosis
Neuromyelitis Optica
/ complications
Optic Neuritis
/ complications
Polymorphism, Genetic
ATP binding cassette gene B1
aquaporin-4 antibody
genetic polymorphisms
high-dose intravenous methylprednisolone
multiple sclerosis
neuromyelitis optica spectrum disorder
optic neuritis
Journal
Journal of clinical pharmacy and therapeutics
ISSN: 1365-2710
Titre abrégé: J Clin Pharm Ther
Pays: England
ID NLM: 8704308
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
23
03
2022
received:
16
02
2022
accepted:
11
04
2022
pubmed:
1
5
2022
medline:
21
9
2022
entrez:
30
4
2022
Statut:
ppublish
Résumé
Patients with optic neuritis (ON) have significant individual differences in their response to high-dose intravenous methylprednisolone (HIMP) therapy. This study aims to evaluate the association between gene polymorphisms and the efficacy of HIMP therapy in Chinese Han patients with ON mediated by aquaporin-4 immunoglobulin G antibody (AQP4-IgG) -positive neuromyelitis optica spectrum disorder (NMOSD) or multiple sclerosis (MS). Chinese Han patients with AQP4-IgG A total of 267 patients completed the follow-up, including 120 patients with AQP4-IgG Our findings suggest that the G > T/A polymorphism of ABCB1 G2677T/A and the TAT/TTT haplotype played a protective role in HIMP treatment of AQP4-IgG
Substances chimiques
ABCB1 protein, human
0
ATP Binding Cassette Transporter, Subfamily B
0
Aquaporin 4
0
Autoantibodies
0
Glucocorticoids
0
Immunoglobulin G
0
Methylprednisolone
X4W7ZR7023
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1379-1387Subventions
Organisme : Foundation of Beijing Science and Technology Project
ID : Z191100007619038
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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