Structural basis for the synthesis of the core 1 structure by C1GalT1.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 05 2022
03 05 2022
Historique:
received:
01
12
2021
accepted:
31
03
2022
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
C1GalT1 is an essential inverting glycosyltransferase responsible for synthesizing the core 1 structure, a common precursor for mucin-type O-glycans found in many glycoproteins. To date, the structure of C1GalT1 and the details of substrate recognition and catalysis remain unknown. Through biophysical and cellular studies, including X-ray crystallography of C1GalT1 complexed to a glycopeptide, we report that C1GalT1 is an obligate GT-A fold dimer that follows a S
Identifiants
pubmed: 35504880
doi: 10.1038/s41467-022-29833-0
pii: 10.1038/s41467-022-29833-0
pmc: PMC9065035
doi:
Substances chimiques
Glycopeptides
0
Mucins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2398Informations de copyright
© 2022. The Author(s).
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