Mapping the developing human immune system across organs.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
03 06 2022
03 06 2022
Historique:
pubmed:
14
5
2022
medline:
7
6
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.
Identifiants
pubmed: 35549310
doi: 10.1126/science.abo0510
pmc: PMC7612819
mid: EMS144959
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabo0510Subventions
Organisme : Wellcome Trust
ID : 220268
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221052
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : European Research Council
ID : 646794
Pays : International
Organisme : Medical Research Council
ID : MR/S035842/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2017-08-ST2-002
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107931
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211276
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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