Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors.

Acetylcholinesterase / metabolism Butyrylcholinesterase / chemistry Cholinesterase Inhibitors / chemistry Molecular Docking Simulation Quinoxalines / pharmacology Structure-Activity Relationship alpha-Amylases / metabolism alpha-Glucosidases / metabolism
Acetylcholinesterases Inhibition Molecular docking Quinoxaline α-Amylase α-Glucosidase

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
30 Jun 2022
Historique:
received: 24 10 2021
revised: 30 04 2022
accepted: 05 05 2022
pubmed: 15 5 2022
medline: 9 6 2022
entrez: 14 5 2022
Statut: ppublish

Résumé

Variety of 2-aryl quinoxaline derivatives 1-23 were synthesized in good yields, by reacting 1,2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of pyridine catalyst. All molecules 1-23 were characterized by spectroscopic techniques and evaluated for their diverse biological potential against α-amylase (α-AMY), α-glucosidase (α-GLU), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. Synthetic derivatives possess enhanced inhibitory potential against all enzymes at nanomolar concentrations. In particular, compound 14 was found much superior with IC

Identifiants

DOI: 10.1016/j.ijbiomac.2022.05.040 PMID: 35568155
pubmed: 35568155
pii: S0141-8130(22)01001-7
doi: 10.1016/j.ijbiomac.2022.05.040
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Quinoxalines 0
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8
alpha-Amylases EC 3.2.1.1
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

653-668

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Shehryar Hameed (S)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Khalid Mohammed Khan (KM)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: khalid.khan@iccs.edu.

Parham Taslimi (P)

Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey.

Uzma Salar (U)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Tugba Taskin-Tok (T)

Gaziantep University, Faculty of Arts and Sciences, Department of Chemistry, Gaziantep, Turkey; Gaziantep University, Institute of Health Sciences, Department of Bioinformatics and Computational Biology, Gaziantep, Turkey.

Dursun Kisa (D)

Department of Molecular Biology and Genetics, Faculty of Science, Bartin University, 74100 Bartin, Turkey.

Faiza Saleem (F)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Mehwish Solangi (M)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Muhammad Hassaan Uddin Ahmed (MHU)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Kiran Rani (K)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoxalines › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Evaluation of synthetic 2-aryl quinoxaline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Evaluation of synthetic 2-aryl quinoxaline...