Spontaneous, co-translational peptide macrocyclization using

Acetylene / analogs & derivatives Cyclization Nitriles Peptide Library Peptides / metabolism Peptides, Cyclic / chemistry Phenylalanine / metabolism

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
09 Jun 2022
Historique:
pubmed: 25 5 2022
medline: 11 6 2022
entrez: 24 5 2022
Statut: epublish

Résumé

Peptide macrocycles (PMCs) are increasingly popular for the development of inhibitors of protein-protein interactions (PPIs). Large libraries of PMCs are accessible using display technologies like mRNA display and phage display. These technologies require macrocyclization chemistries to be compatible with biological milieu, severely limiting the types of technologies available for cyclization. Here, we introduce the novel non-canonical amino acid (ncAA)

Identifiants

DOI: 10.1039/d2cc01148d PMID: 35607950
pubmed: 35607950
doi: 10.1039/d2cc01148d
doi:

Substances chimiques

Nitriles 0
Peptide Library 0
Peptides 0
Peptides, Cyclic 0
cyanoacetylene 0
Phenylalanine 47E5O17Y3R
Acetylene OC7TV75O83

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6737-6740

Auteurs

H Estheban Osorio Franco (HEO)

Massey Cancer Center, Virginia Commonwealth University, 401 College St, Richmond, 23219, Virginia, USA. osoriofranche@vcu.edu.
Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23284, VA, USA.

Brennan T Chaloux (BT)

Massey Cancer Center, Virginia Commonwealth University, 401 College St, Richmond, 23219, Virginia, USA. osoriofranche@vcu.edu.
Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23284, VA, USA.

Matthew C T Hartman (MCT)

Massey Cancer Center, Virginia Commonwealth University, 401 College St, Richmond, 23219, Virginia, USA. osoriofranche@vcu.edu.
Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23284, VA, USA.
ORCID: 0000-0003-0210-1422

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcynes › Acétylène › Spontaneous, co-translational peptide...
questionsmedicales.fr › Métabolisme › Cyclisation › Spontaneous, co-translational peptide...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Spontaneous, co-translational peptide...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Banque de gènes › Banque de peptides › Spontaneous, co-translational peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Spontaneous, co-translational peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Spontaneous, co-translational peptide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Phénylalanine › Spontaneous, co-translational peptide...