Whole-proteome structures shed new light on posttranslational modifications.

Protein Processing, Post-Translational Proteome / metabolism Proteomics / methods

Journal

PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755

Informations de publication

Date de publication:
05 2022
Historique:
revised: 09 06 2022
pubmed: 28 5 2022
medline: 14 6 2022
entrez: 27 5 2022
Statut: epublish

Résumé

Accurate but protein-only AlphaFold models may show structural fingerprints of likely posttranslational modifications (PTMs). In this issue of PLOS Biology, Bludau and colleagues add a functional context to models by combining them with readily available proteomics results.

Identifiants

DOI: 10.1371/journal.pbio.3001673 PMID: 35622853 PMC: PMC9182549
pubmed: 35622853
doi: 10.1371/journal.pbio.3001673
pii: PBIOLOGY-D-22-00940
pmc: PMC9182549
doi:

Substances chimiques

Proteome 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

e3001673

Commentaires et corrections

Type : CommentOn

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

Bioinformatics. 2015 Mar 15;31(6):926-32
pubmed: 25398609
Nat Biotechnol. 2020 Mar;38(3):365-373
pubmed: 31819260
Science. 2021 Aug 20;373(6557):871-876
pubmed: 34282049
Cell Rep. 2014 Sep 11;8(5):1583-94
pubmed: 25159151
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Nat Struct Mol Biol. 2021 Nov;28(11):869-870
pubmed: 34716446
PLoS Biol. 2022 May 16;20(5):e3001636
pubmed: 35576205
Curr Opin Chem Biol. 2009 Oct;13(4):421-6
pubmed: 19700364
Nature. 2021 Aug;596(7873):590-596
pubmed: 34293799

Auteurs

Robbie P Joosten (RP)

Biochemistry Department, Netherlands Cancer Institute, the Netherlands and Oncode Institute, Amsterdam, the Netherlands.

Jon Agirre (J)

York Structural Biology Laboratory, Department of Chemistry, University of York, York, United Kingdom.
ORCID: 0000-0002-1086-0253

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Whole-proteome structures shed new light on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Whole-proteome structures shed new light on...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Whole-proteome structures shed new light on...