Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms.
Biofuels
Metabolic engineering
Microbial cell factories
Non-canonical amino acids
Non-natural biomolecules
Xeno nucleic acids
Journal
Microbial cell factories
ISSN: 1475-2859
Titre abrégé: Microb Cell Fact
Pays: England
ID NLM: 101139812
Informations de publication
Date de publication:
28 May 2022
28 May 2022
Historique:
received:
05
01
2022
accepted:
15
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
The surging demand of value-added products has steered the transition of laboratory microbes to microbial cell factories (MCFs) for facilitating production of large quantities of important native and non-native biomolecules. This shift has been possible through rewiring and optimizing different biosynthetic pathways in microbes by exercising frameworks of metabolic engineering and synthetic biology principles. Advances in genome and metabolic engineering have provided a fillip to create novel biomolecules and produce non-natural molecules with multitude of applications. To this end, numerous MCFs have been developed and employed for production of non-natural nucleic acids, proteins and different metabolites to meet various therapeutic, biotechnological and industrial applications. The present review describes recent advances in production of non-natural amino acids, nucleic acids, biofuel candidates and platform chemicals.
Identifiants
pubmed: 35643549
doi: 10.1186/s12934-022-01828-y
pii: 10.1186/s12934-022-01828-y
pmc: PMC9148472
doi:
Substances chimiques
Nucleic Acids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100Informations de copyright
© 2022. The Author(s).
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