Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G
Amyotrophic Lateral Sclerosis
/ drug therapy
Animals
C9orf72 Protein
/ genetics
DNA Repeat Expansion
Decitabine
/ metabolism
Dipeptides
/ metabolism
Frontotemporal Dementia
/ genetics
Humans
Induced Pluripotent Stem Cells
/ metabolism
Mice
Neurons
/ metabolism
Nucleosides
/ metabolism
RNA, Antisense
/ metabolism
ALS
C9orf72
CP: Neuroscience
DPR
FTD
RAN translation
RNA foci
iPSC neurons
nucleoside analogs
repeat expansion
screening
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
received:
19
05
2021
revised:
22
12
2021
accepted:
12
05
2022
entrez:
8
6
2022
pubmed:
9
6
2022
medline:
11
6
2022
Statut:
ppublish
Résumé
An intronic (G
Identifiants
pubmed: 35675776
pii: S2211-1247(22)00690-8
doi: 10.1016/j.celrep.2022.110913
pii:
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
Dipeptides
0
Nucleosides
0
RNA, Antisense
0
Decitabine
776B62CQ27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110913Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests T.K. and J.M. are employees of Orion Pharma. The other authors declare no competing interests.