How Do Phenolic Acids Change the Secondary and Tertiary Structure of Gliadin? Studies with an Application of Spectroscopic Techniques.
FTIR technique
gliadin
phenolic acids
secondary structure
time-resolved fluorescence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 May 2022
27 May 2022
Historique:
received:
29
04
2022
revised:
25
05
2022
accepted:
26
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
The effect of the chemical structure of selected phenolic acids on the molecular organization of gliadins was investigated with the application of Fourier Transform Infrared (FTIR) technique, steady-state, and time-resolved fluorescence spectroscopy. Hydroxybenzoic (4-hydroxybenzoic, protocatechuic, vanillic, and syringic) and hydroxycinnamic (coumaric, caffeic, ferulic, sinapic) acids have been used as gliadins modifiers. The results indicated that hydroxybenzoic acids due to their smaller size incorporate into spaces between two polypeptide chains and form a hydrogen bond with them leading to aggregation. Additionally, syringic acids could incorporate into hydrophobic pockets of protein. Whereas hydroxycinnamic acids, due to their higher stiffness and larger size, separated polypeptide chains leading to gliadin disaggregation. These acids did not incorporate into hydrophobic pockets.
Identifiants
pubmed: 35682729
pii: ijms23116053
doi: 10.3390/ijms23116053
pmc: PMC9181179
pii:
doi:
Substances chimiques
Coumaric Acids
0
Hydroxybenzoates
0
Gliadin
9007-90-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Polish Academy of Sciences
ID : OPUS 18 2019/35/B/NZ9/02854
Références
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 15;229:117937
pubmed: 31865099
Food Chem. 2017 Sep 15;231:51-60
pubmed: 28450023
Biochem Pharmacol. 2017 Sep 1;139:40-55
pubmed: 28390938
Biochemistry. 2012 Apr 3;51(13):2670-83
pubmed: 22409724
Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8370-8382
pubmed: 29446868
Anim Nutr. 2020 Jun;6(2):115-123
pubmed: 32542190
Food Funct. 2019 Feb 20;10(2):514-528
pubmed: 30746536
Molecules. 2021 Jan 19;26(2):
pubmed: 33478043
J Biol Chem. 2013 Aug 9;288(32):23212-24
pubmed: 23792961
Food Chem. 2011 Dec 1;129(3):1100-7
pubmed: 25212343
Adv Colloid Interface Sci. 2019 Jul;269:334-356
pubmed: 31128463
J Ethnopharmacol. 2012 Aug 30;143(1):185-93
pubmed: 22732728
J Control Release. 2012 Jul 10;161(1):38-49
pubmed: 22564368
Food Chem. 2018 Jun 30;252:198-206
pubmed: 29478532
Sci Rep. 2017 Aug 25;7(1):9470
pubmed: 28842631
Nutr Cancer. 2006;56(2):182-92
pubmed: 17474864
Food Chem. 2011 Aug 1;127(3):1046-55
pubmed: 25214095
Food Chem. 2012 Dec 15;135(4):2418-24
pubmed: 22980822
Ann N Y Acad Sci. 1973 Jun 15;209:154-62
pubmed: 4515031
J Pept Sci. 2009 Jan;15(1):23-9
pubmed: 19023881
J Agric Food Chem. 2005 Mar 9;53(5):1757-64
pubmed: 15740070
J Fluoresc. 2014 Jan;24(1):93-104
pubmed: 23912963
Food Chem. 2013 Dec 15;141(4):3586-97
pubmed: 23993525
J Agric Food Chem. 2016 Mar 16;64(10):2094-104
pubmed: 26927821