Discovery of novel phenoxypyridine as promising protoporphyrinogen IX oxidase inhibitors.

Enzyme Inhibitors / chemistry Herbicides / chemistry Molecular Docking Simulation Protoporphyrinogen Oxidase Structure-Activity Relationship
Cumulative analysis Field trial Greenhouse herbicidal activity Oxime ester PPO

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 04 01 2022
revised: 30 03 2022
accepted: 15 04 2022
entrez: 17 6 2022
pubmed: 18 6 2022
medline: 22 6 2022
Statut: ppublish

Résumé

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a significant target for the discovery of novel bleaching herbicides. Starting from the active fragments of several known commercial herbicides, a series of PPO inhibitors with diphenyl ether scaffolds were designed and synthesized by substructure splicing and bioisosterism methods. The greenhouse herbicidal activity and the PPO inhibitory activity in vitro were measured. The results showed that the novel synthesized compounds have good PPO inhibitory activity, and the IC

Identifiants

DOI: 10.1016/j.pestbp.2022.105102 PMID: 35715041
pubmed: 35715041
pii: S0048-3575(22)00069-4
doi: 10.1016/j.pestbp.2022.105102
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Herbicides 0
Protoporphyrinogen Oxidase EC 1.3.3.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105102

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Li-Xia Zhao (LX)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Jian-Feng Peng (JF)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Feng-Yi Liu (FY)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Yue-Li Zou (YL)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Shuang Gao (S)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Ying Fu (Y)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China. Electronic address: fuying@neau.edu.cn.

Fei Ye (F)

Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China. Electronic address: yefei@neau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Discovery of novel phenoxypyridine as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Herbicides › Discovery of novel phenoxypyridine as...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of novel phenoxypyridine as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protoporphyrinogen oxidase › Discovery of novel phenoxypyridine as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of novel phenoxypyridine as...