The Golgi complex: An organelle that determines urothelial cell biology in health and disease.
Bladder cancer
Blood–urine barrier
Differentiation
Golgi complex
Uroplakins
Urothelium
Journal
Histochemistry and cell biology
ISSN: 1432-119X
Titre abrégé: Histochem Cell Biol
Pays: Germany
ID NLM: 9506663
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
accepted:
24
05
2022
pubmed:
1
7
2022
medline:
26
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
The Golgi complex undergoes considerable structural remodeling during differentiation of urothelial cells in vivo and in vitro. It is known that in a healthy bladder the differentiation from the basal to the superficial cell layer leads to the formation of the tightest barrier in our body, i.e., the blood-urine barrier. In this process, urothelial cells start expressing tight junctional proteins, apical membrane lipids, surface glycans, and integral membrane proteins, the uroplakins (UPs). The latter are the most abundant membrane proteins in the apical plasma membrane of differentiated superficial urothelial cells (UCs) and, in addition to well-developed tight junctions, contribute to the permeability barrier by their structural organization and by hindering endocytosis from the apical plasma membrane. By studying the transport of UPs, we were able to demonstrate their differentiation-dependent effect on the Golgi architecture. Although fragmentation of the Golgi complex is known to be associated with mitosis and apoptosis, we found that the process of Golgi fragmentation is required for delivery of certain specific urothelial differentiation cargoes to the plasma membrane as well as for cell-cell communication. In this review, we will discuss the currently known contribution of the Golgi complex to the formation of the blood-urine barrier in normal UCs and how it may be involved in the loss of the blood-urine barrier in cancer. Some open questions related to the Golgi complex in the urothelium will be highlighted.
Identifiants
pubmed: 35773494
doi: 10.1007/s00418-022-02121-0
pii: 10.1007/s00418-022-02121-0
pmc: PMC9399047
doi:
Substances chimiques
Membrane Proteins
0
Uroplakins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-240Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J7-2594
Organisme : INTAS
ID : 99-4-1732
Informations de copyright
© 2022. The Author(s).
Références
Int J Mol Sci. 2021 May 25;22(11):
pubmed: 34070317
J Urol. 1978 Jul;120(1):43-7
pubmed: 566801
Mol Biol Cell. 2003 Nov;14(11):4470-85
pubmed: 12937271
Cell. 2011 Feb 18;144(4):590-600
pubmed: 21335240
PLoS One. 2015 Sep 11;10(9):e0137878
pubmed: 26361392
Mol Biosyst. 2016 Oct 18;12(11):3266-3279
pubmed: 27527902
Am J Pathol. 1998 Dec;153(6):1957-67
pubmed: 9846985
Histochem Cell Biol. 2005 Jun;123(4-5):529-39
pubmed: 15868181
Life Sci. 2020 Nov 1;260:118294
pubmed: 32818544
J Biol Chem. 1994 May 6;269(18):13716-24
pubmed: 8175808
J Cell Physiol. 2006 Aug;208(2):407-17
pubmed: 16688762
Histochem Cell Biol. 2011 Oct;136(4):491-500
pubmed: 21853341
Mol Phylogenet Evol. 2006 Nov;41(2):355-67
pubmed: 16814572
Cell Death Differ. 2011 Apr;18(4):732-42
pubmed: 21113142
Ann N Y Acad Sci. 2009 Jan;1152:18-29
pubmed: 19161373
J Clin Invest. 2007 Nov;117(11):3453-62
pubmed: 17948126
Annu Rev Cell Dev Biol. 2016 Oct 6;32:373-397
pubmed: 27146312
Int J Mol Sci. 2022 Mar 25;23(7):
pubmed: 35408951
Biochim Biophys Acta. 2000 Jul 26;1475(3):231-7
pubmed: 10913821
Physiol Rev. 2013 Apr;93(2):653-80
pubmed: 23589830
Sci Rep. 2017 Oct 9;7(1):12842
pubmed: 28993693
Virology. 1996 Jul 15;221(2):325-34
pubmed: 8661443
Radiol Oncol. 2020 May 2;54(2):135-143
pubmed: 32374292
Front Neurosci. 2015 Sep 24;9:340
pubmed: 26441511
Biochem Mol Biol J. 2015;1(1):
pubmed: 27064441
Science. 2004 Feb 13;303(5660):1007-10
pubmed: 14963329
Am J Transl Res. 2021 Nov 15;13(11):12509-12522
pubmed: 34956469
J Cell Biol. 1966 Sep;30(3):623-43
pubmed: 5971009
Radiol Oncol. 2013 Oct 08;47(4):338-45
pubmed: 24294178
Cell Tissue Res. 2009 Jun;336(3):453-63
pubmed: 19370362
Anat Rec. 1982 Aug;203(4):429-40
pubmed: 7137597
J Mol Biol. 1999 Jan 15;285(2):595-608
pubmed: 9878432
Eur J Cell Biol. 2004 Feb;83(1):27-34
pubmed: 15085953
Histochem Cell Biol. 1999 Nov;112(5):375-80
pubmed: 10603077
PLoS One. 2014 Jun 19;9(6):e99196
pubmed: 24945745
Nature. 2020 Dec;588(7837):290-295
pubmed: 33057202
Biol Rev Camb Philos Soc. 1975 May;50(2):215-46
pubmed: 1100129
J Cell Biol. 1990 Sep;111(3):1207-16
pubmed: 1697295
Lab Invest. 1969 Aug;21(2):154-68
pubmed: 5804627
FEBS Lett. 2009 Dec 3;583(23):3738-45
pubmed: 19837068
J Pathol. 2003 Jan;199(1):41-9
pubmed: 12474225
JCI Insight. 2021 Oct 8;6(19):
pubmed: 34464353
J Clin Invest. 2005 Sep;115(9):2412-22
pubmed: 16110327
Rev Physiol Biochem Pharmacol. 2015;168:1-29
pubmed: 25851229
Am J Physiol Renal Physiol. 2002 Dec;283(6):F1200-7
pubmed: 12388410
J Ultrastruct Res. 1979 Nov;69(2):279-96
pubmed: 490764
Sci Rep. 2020 Jun 29;10(1):10555
pubmed: 32601379
PLoS One. 2012;7(3):e32935
pubmed: 22427911
J Cell Biol. 2002 Feb 4;156(3):495-509
pubmed: 11815631
Curr Opin Cell Biol. 2017 Aug;47:43-51
pubmed: 28390244
Histochem Cell Biol. 2008 Feb;129(2):153-61
pubmed: 18214517
BMC Evol Biol. 2014 Jan 23;14:13
pubmed: 24450554
J Biol Chem. 2006 May 26;281(21):14644-53
pubmed: 16567801
Urology. 2007 Apr;69(4 Suppl):9-16
pubmed: 17462486
PLoS One. 2012;7(6):e38509
pubmed: 22768045
J Cell Biol. 1994 Apr;125(1):171-82
pubmed: 8138569
Cell Biol Int. 2002;26(1):63-74
pubmed: 11779222
Mol Biol Cell. 2018 Dec 15;29(26):3128-3143
pubmed: 30303751
Cell Motil Cytoskeleton. 2002 Dec;53(4):317-25
pubmed: 12378541
PLoS One. 2020 Aug 13;15(8):e0237514
pubmed: 32790781
Int J Urol. 2008 Aug;15(8):681-7
pubmed: 18462357
Histol Histopathol. 2011 Jan;26(1):117-33
pubmed: 21117033
Histol Histopathol. 2021 Jan;36(1):47-60
pubmed: 33078843
J Anat. 1989 Dec;167:103-15
pubmed: 2630525
Front Cell Dev Biol. 2019 Aug 07;7:146
pubmed: 31440506
Stem Cells Int. 2017;2017:6917941
pubmed: 28659978
Front Cell Dev Biol. 2021 May 12;9:665289
pubmed: 34055798
Protoplasma. 2010 Oct;246(1-4):3-14
pubmed: 20521071
Biochem J. 2001 Apr 1;355(Pt 1):13-8
pubmed: 11256943
Appl Immunohistochem Mol Morphol. 2002 Dec;10(4):339-43
pubmed: 12607602
Nature. 1970 Jul 18;227(5255):280-1
pubmed: 5428195
Tissue Cell. 2017 Apr;49(2 Pt A):186-201
pubmed: 28007425
Differentiation. 2009 Jan;77(1):48-59
pubmed: 19281764
Histochem Cell Biol. 2013 May;139(5):671-84
pubmed: 23212845
Biochem J. 2008 Sep 1;414(2):195-203
pubmed: 18481938
Front Neurosci. 2015 Nov 06;9:421
pubmed: 26594142
Mol Biol Cell. 2002 Dec;13(12):4221-30
pubmed: 12475947
J Cell Sci. 2003 Oct 15;116(Pt 20):4087-94
pubmed: 12972502
Microorganisms. 2022 Apr 07;10(4):
pubmed: 35456833
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1230-9
pubmed: 24639524
Histochem Cell Biol. 2017 Aug;148(2):143-156
pubmed: 28397141
Eur Urol. 2021 Jan;79(1):82-104
pubmed: 32360052
Bladder (San Franc). 2015;2(1):e9
pubmed: 26269793
Oncotarget. 2015 Oct 13;6(31):32177-92
pubmed: 26375441
J Biol Chem. 1990 Nov 5;265(31):19170-9
pubmed: 2229070
Physiol Rev. 2020 Oct 1;100(4):1621-1705
pubmed: 32191559
Tissue Eng Part C Methods. 2014 Apr;20(4):317-27
pubmed: 23947657
Biomed Res Int. 2014;2014:297295
pubmed: 25177686
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1477-501
pubmed: 19587142
Biol Cell. 2010 Nov;102(11):593-607
pubmed: 20735355
In Vitro Cell Dev Biol Anim. 2013 Mar;49(3):196-204
pubmed: 23408058
Protoplasma. 2014 Jan;251(1):49-59
pubmed: 23828036
Mol Cell Biochem. 2009 Oct;330(1-2):163-9
pubmed: 19412731
PLoS One. 2011;6(8):e23636
pubmed: 21887288
J Membr Biol. 1976 Aug 27;28(1):1-40
pubmed: 9512
Traffic. 2000 Dec;1(12):963-75
pubmed: 11208086
Cell Tissue Res. 2005 May;320(2):259-68
pubmed: 15778856
Int J Mol Sci. 2021 Sep 07;22(18):
pubmed: 34575851
J Lipid Res. 2019 Feb;60(2):269-275
pubmed: 30266835
J Cell Biol. 2000 Nov 27;151(5):961-72
pubmed: 11085999
Histochem Cell Biol. 1996 Jul;106(1):79-92
pubmed: 8858368