Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition.

DNA RNA apyromidinic sites c-kit c-myc naphthalene diimide nucleobase inclusion parallel G-quadruplex telomere RNA β-cyclodextrins (β-CyDs)

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
23 Jun 2022
Historique:
received: 25 04 2022
revised: 20 06 2022
accepted: 21 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 14 7 2022
Statut: epublish

Résumé

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.

Identifiants

pubmed: 35807292
pii: molecules27134053
doi: 10.3390/molecules27134053
pmc: PMC9268153
pii:
doi:

Substances chimiques

Imides 0
Ligands 0
Naphthalenes 0
beta-Cyclodextrins 0
naphthalenediimide 22291-04-9
RNA 63231-63-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology,
ID : 19H02748
Organisme : Nakatani Foundation for advancement of measuring technologies in biomedical engineering
ID : S.T.

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Auteurs

Tingting Zou (T)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Yuka Sato (Y)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Shuma Kaneyoshi (S)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Kota Mano (K)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Rui Yasukawa (R)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Yoshifumi Nakano (Y)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Satoshi Fujii (S)

Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan.

Shinobu Sato (S)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

Shigeori Takenaka (S)

Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.

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Classifications MeSH