Biotechnological interventions and indole alkaloid production in Rauvolfia serpentina.
Agrobacterium
Hairy root culture
Indole alkaloids
Micropropagation
Plant growth regulators
Rauvolfia serpentina
Reserpine
Synthetic seed
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
02
04
2022
accepted:
18
06
2022
revised:
16
06
2022
pubmed:
13
7
2022
medline:
30
7
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
Rauvolfia serpentina (L). Benth. ex Kurz. (Apocynaceae), commonly known as Sarpagandha or Indian snakeroot, has long been used in the traditional treatment of snakebites, hypertension, and mental illness. The plant is known to produce an array of indole alkaloids such as reserpine, ajmaline, amalicine, etc. which show immense pharmacological and biomedical significance. However, owing to its poor seed viability, lesser germination rate and overexploitation for several decades for its commercially important bioactive constituents, the plant has become endangered in its natural habitat. The present review comprehensively encompasses the various biotechnological tools employed in this endangered Ayurvedic plant for its in vitro propagation, role of plant growth regulators and additives in direct and indirect regeneration, somatic embryogenesis and synthetic seed production, secondary metabolite production in vitro, and assessment of clonal fidelity using molecular markers and genetic transformation. In addition, elicitation and other methods of optimization of its indole-alkaloids are also described herewith. KEY POINTS: • Latest literature on in vitro propagation of Rauvolfia serpentina • Biotechnological production and optimization of indole alkaloids • Clonal fidelity and transgenic studies in R. serpentina.
Identifiants
pubmed: 35819514
doi: 10.1007/s00253-022-12040-8
pii: 10.1007/s00253-022-12040-8
doi:
Substances chimiques
Indole Alkaloids
0
Secologanin Tryptamine Alkaloids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4867-4883Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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