Bola-Amphiphilic Glycodendrimers: New Carbohydrate-Mimicking Scaffolds to Target Carbohydrate-Binding Proteins.
bola-amphiphiles
glucose transporters
glycodendrimers
mannose receptors
targeted delivery
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
18 Oct 2022
18 Oct 2022
Historique:
received:
06
05
2022
pubmed:
13
7
2022
medline:
22
10
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.
Identifiants
pubmed: 35820051
doi: 10.1002/chem.202201400
doi:
Substances chimiques
Mannose
PHA4727WTP
Dendrimers
0
Reactive Oxygen Species
0
Carbohydrates
0
Lectins
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202201400Subventions
Organisme : National Natural Science Foundation of China
ID : 81502920, YX
Organisme : Graduate Research and Innovation Foundation of Chongqing
ID : CYB19066, WZ
Organisme : Campus France PHC CAI YUAN PEI program
ID : YX, JLI
Organisme : Orchid program
ID : LP,C-LK
Organisme : China Scholarship Council
ID : WZ
Organisme : Bourse d'Excellence Eiffel
ID : Y-WY
Organisme : Bourses d'excellence PACA
ID : Y-WY
Organisme : Ligue Nationale Contre le Cancer
ID : EL2021 LNCCLiP, LP
Organisme : Ministry of Science and Technology of Taiwan
ID : 109-2923-M-037-001-MY3
Organisme : Ministry of Education of Taiwan Scholarship for Excellent Students to Study Abroad or Overseas Internship Training
ID : Y-WY
Organisme : French National Research Agency and the National Centre for Research and Development in Poland under the frame of H2020 Era-Net EURONANOMED European Research project 'NANOGLIO'
ID : LP, BK
Organisme : French National Research Agency and the National Centre for Research and Development in Poland under the frame of H2020 Era-Net EURONANOMED European Research project 'iNANOGUN'
ID : LP, BK
Organisme : French National Research Agency and the National Centre for Research and Development in Poland under the frame of H2020 Era-Net EURONANOMED European Research project 'NAN4TUM'
ID : LP, C-LK
Organisme : EU H2020 Research and Innovation program NMBP "SAFE-N-MEDTECH" (2019-2023)
ID : 814607
Organisme : H2020 Marie Skłodowska-Curie Innovative Training Network "OLIGOMED" (2021-2024)
ID : 956070
Organisme : Italian Association for Cancer Research (IG17413)
ID : SP
Informations de copyright
© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
Références
Chem Rev. 2021 Sep 22;121(18):10950-11029
pubmed: 34338501
Front Immunol. 2018 Jun 15;9:1329
pubmed: 29963047
Front Immunol. 2021 Oct 14;12:765034
pubmed: 34721436
J Am Chem Soc. 2002 Sep 11;124(36):10773-8
pubmed: 12207533
Chem Rev. 2002 Feb;102(2):555-78
pubmed: 11841254
J Biotechnol. 2002 May;90(3-4):231-55
pubmed: 12071227
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1162-7
pubmed: 26787853
Chemistry. 2022 Oct 18;28(58):e202201400
pubmed: 35820051
Chem Commun (Camb). 2020 May 14;56(39):5207-5222
pubmed: 32322844
Biomacromolecules. 2012 Nov 12;13(11):3581-91
pubmed: 23017146
Chem Rev. 2004 Jun;104(6):2901-37
pubmed: 15186184
Science. 2001 Mar 23;291(5512):2357-64
pubmed: 11269316
Front Chem. 2021 Jan 20;8:604151
pubmed: 33553103
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):11931-11939
pubmed: 32424105
J Biol Chem. 2000 May 12;275(19):14223-30
pubmed: 10799500
Chem Soc Rev. 2020 May 7;49(9):2531-2545
pubmed: 32191228
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8478-84
pubmed: 22829421
FEBS J. 2018 Aug;285(16):2926-2943
pubmed: 29893496
Int J Biol Macromol. 2019 Aug 1;134:901-911
pubmed: 31108148
Biophys Rev. 2016 Mar;8(1):5-9
pubmed: 28510148
Biomacromolecules. 2020 Dec 14;21(12):5345-5357
pubmed: 33307698
Chem Soc Rev. 2015 Jun 21;44(12):3924-41
pubmed: 25556902
Science. 1989 Oct 13;246(4927):227-34
pubmed: 2552581
Molecules. 2014 Jan 17;19(1):1120-49
pubmed: 24445341
Molecules. 2021 Apr 22;26(9):
pubmed: 33921945
Chem Soc Rev. 2016 Jun 7;45(11):3275-302
pubmed: 27146554
Angew Chem Int Ed Engl. 2014 Oct 6;53(41):11079-83
pubmed: 25160663
Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10899-903
pubmed: 24923471
J Biol Chem. 2021 Jan-Jun;296:100368
pubmed: 33545173