Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (Phase Active du Second STade trial) among nulliparous women with an epidural.


Journal

American journal of obstetrics and gynecology
ISSN: 1097-6868
Titre abrégé: Am J Obstet Gynecol
Pays: United States
ID NLM: 0370476

Informations de publication

Date de publication:
10 2022
Historique:
received: 07 03 2022
revised: 12 07 2022
accepted: 14 07 2022
pubmed: 23 7 2022
medline: 5 10 2022
entrez: 22 7 2022
Statut: ppublish

Résumé

There is no consensus on an optimal strategy for managing the active phase of the second stage of labor. Intensive pushing could not only reduce pushing duration, but also increase abnormal fetal heart rate because of cord compression and reduced placental perfusion and oxygenation resulting from the combination of uterine contractions and maternal expulsive forces. Therefore, it may increase the risk of neonatal acidosis and the need for operative vaginal delivery. This study aimed to assess the effect of the management encouraging "moderate" pushing vs "intensive" pushing on neonatal morbidity. This study was a multicenter randomized controlled trial, including nulliparas in the second stage of labor with an epidural and a singleton cephalic fetus at term and with a normal fetal heart rate. Of note, 2 groups were defined: (1) the moderate pushing group, in which women had no time limit on pushing, pushed only twice during each contraction, and observed regular periods without pushing, and (2) the intensive pushing group, in which women pushed 3 times during each contraction and the midwife called an obstetrician after 30 minutes of pushing to discuss operative delivery (standard care). The primary outcome was a composite neonatal morbidity criterion, including umbilical arterial pH of <7.15, base excess of >10 mmol/L, lactate levels of >6 mmol/L, 5-minute Apgar score of <7, and severe neonatal trauma. The secondary outcomes were mode of delivery, episiotomy, obstetrical anal sphincter injuries, postpartum hemorrhage, and maternal satisfaction. The study included 1710 nulliparous women. The neonatal morbidity rate was 18.9% in the moderate pushing group and 20.6% in the intensive pushing group (P=.38). Pushing duration was longer in the moderate group than in the intensive group (38.8±26.4 vs 28.6±17.0 minutes; P<.001), and its rate of operative delivery was 21.1% in the moderate group compared with 24.8% in the intensive group (P=.08). The episiotomy rate was significantly lower in the moderate pushing group than in the intensive pushing group (13.5% vs 17.8%; P=.02). We found no significant difference for obstetrical anal sphincter injuries, postpartum hemorrhage, or maternal satisfaction. Moderate pushing has no effect on neonatal morbidity, but it may nonetheless have benefits, as it was associated with a lower episiotomy rate.

Sections du résumé

BACKGROUND
There is no consensus on an optimal strategy for managing the active phase of the second stage of labor. Intensive pushing could not only reduce pushing duration, but also increase abnormal fetal heart rate because of cord compression and reduced placental perfusion and oxygenation resulting from the combination of uterine contractions and maternal expulsive forces. Therefore, it may increase the risk of neonatal acidosis and the need for operative vaginal delivery.
OBJECTIVE
This study aimed to assess the effect of the management encouraging "moderate" pushing vs "intensive" pushing on neonatal morbidity.
STUDY DESIGN
This study was a multicenter randomized controlled trial, including nulliparas in the second stage of labor with an epidural and a singleton cephalic fetus at term and with a normal fetal heart rate. Of note, 2 groups were defined: (1) the moderate pushing group, in which women had no time limit on pushing, pushed only twice during each contraction, and observed regular periods without pushing, and (2) the intensive pushing group, in which women pushed 3 times during each contraction and the midwife called an obstetrician after 30 minutes of pushing to discuss operative delivery (standard care). The primary outcome was a composite neonatal morbidity criterion, including umbilical arterial pH of <7.15, base excess of >10 mmol/L, lactate levels of >6 mmol/L, 5-minute Apgar score of <7, and severe neonatal trauma. The secondary outcomes were mode of delivery, episiotomy, obstetrical anal sphincter injuries, postpartum hemorrhage, and maternal satisfaction.
RESULTS
The study included 1710 nulliparous women. The neonatal morbidity rate was 18.9% in the moderate pushing group and 20.6% in the intensive pushing group (P=.38). Pushing duration was longer in the moderate group than in the intensive group (38.8±26.4 vs 28.6±17.0 minutes; P<.001), and its rate of operative delivery was 21.1% in the moderate group compared with 24.8% in the intensive group (P=.08). The episiotomy rate was significantly lower in the moderate pushing group than in the intensive pushing group (13.5% vs 17.8%; P=.02). We found no significant difference for obstetrical anal sphincter injuries, postpartum hemorrhage, or maternal satisfaction.
CONCLUSION
Moderate pushing has no effect on neonatal morbidity, but it may nonetheless have benefits, as it was associated with a lower episiotomy rate.

Identifiants

pubmed: 35868416
pii: S0002-9378(22)00579-8
doi: 10.1016/j.ajog.2022.07.025
pii:
doi:

Substances chimiques

Lactates 0

Banques de données

ClinicalTrials.gov
['NCT03018860']

Types de publication

Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

639.e1-639.e15

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Camille Le Ray (C)

Assistance Publique-Hôpitaux de Paris, Maternity Port Royal, Fighting Prematurity University Hospital Federation, Paris, France; Obstetrical Perinatal and Pediatric Epidemiology Research Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research, French National Institute for Agricultural Research, University of Paris, Paris, France. Electronic address: camille.le-ray@aphp.fr.

Patrick Rozenberg (P)

Service d'Obstétrique et Gynécologie, Centre Hospitalier Intercommunal Poissy-Saint Germain, Poissy, France; Université Paris Saclay, University of Versailles Saint-Quentin-en-Yvelines, French National Institute of Health and Medical Research, Epidémiologie Clinique, Centre for Research in Epidemiology and Population Health, Montigny-le-Bretonneux, France.

Gilles Kayem (G)

Obstetrical Perinatal and Pediatric Epidemiology Research Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research, French National Institute for Agricultural Research, University of Paris, Paris, France; Assistance Publique-Hôpitaux de Paris, Service d'Obstétrique et Gynécologie, Hôpital Trousseau, Fighting Prematurity University Hospital Federation, Paris, France.

Thierry Harvey (T)

Hospital Group Diaconesses Croix Saint-Simon (Groupe Hospitalier Diaconesses Croix Saint-Simon), Paris, France.

Jeanne Sibiude (J)

Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Colombes, France; Infection, Antimicrobials, Modelling, Evolution, National Institute of Health and Medical Research, Université de Paris, Paris, France.

Muriel Doret (M)

Department of Obstetrics and Gynecology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.

Olivier Parant (O)

Hospital Center University De Toulouse, Pole de Gynécologie Obstétrique, Hospital Paule De Viguier, Toulouse, France.

Florent Fuchs (F)

Montpellier Department of Obstetrics and Gynecology, University Hospital Center, Montpellier, France; Reproduction and Child Development, National Institute of Health and Medical Research, Centre for Research in Epidemiology and Population Health, Villejuif, France; Desbret Institute of Epidemiology and Public Health, University of Montpellier, Montpellier, France.

Delphine Vardon (D)

Department of Obstetrics and Gynecology, Pôle Femme-Enfant, Caen University Hospital, Caen, France.

Elie Azria (E)

Obstetrical Perinatal and Pediatric Epidemiology Research Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research, French National Institute for Agricultural Research, University of Paris, Paris, France; Maternity Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France.

Marie-Victoire Sénat (MV)

Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, University Paris Saclay, Le Kremlin-Bicêtre, France.

Pierre-François Ceccaldi (PF)

Assistance Publique-Hôpitaux de Paris, Service de Gynécologie-Obstétrique, Centre Hospitalo-Universitaire Beaujon Clichy-la-garenne, Université de Paris, France.

Aurélien Seco (A)

Obstetrical Perinatal and Pediatric Epidemiology Research Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research, French National Institute for Agricultural Research, University of Paris, Paris, France; Clinical Research Unit Necker/Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.

Charles Garabedian (C)

Department of Obstetrics, Centre Hospitalier Universitaire de Lille, University of Lille, Lille, France.

Anne Alice Chantry (AA)

Obstetrical Perinatal and Pediatric Epidemiology Research Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, National Institute of Health and Medical Research, French National Institute for Agricultural Research, University of Paris, Paris, France.

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