Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
12
05
2022
accepted:
08
07
2022
pubmed:
26
7
2022
medline:
7
12
2022
entrez:
25
7
2022
Statut:
ppublish
Résumé
Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included seven cohorts: the Million Veteran Program, Psychiatric Genomics Consortium, iPSYCH, FinnGen, Partners Biobank, BioVU, and Yale-Penn 3, resulting in a total N = 639,063 (N
Identifiants
pubmed: 35879402
doi: 10.1038/s41380-022-01709-1
pii: 10.1038/s41380-022-01709-1
pmc: PMC9718667
doi:
Substances chimiques
Furin
EC 3.4.21.75
OPRM1 protein, human
0
Types de publication
Meta-Analysis
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3970-3979Subventions
Organisme : NIDA NIH HHS
ID : K02 DA032573
Pays : United States
Organisme : BLRD VA
ID : I01 BX004820
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA054869
Pays : United States
Organisme : NIAAA NIH HHS
ID : U10 AA013566
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA020794
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA028259
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA051906
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA022001
Pays : United States
Organisme : NIDA NIH HHS
ID : DP1 DA054394
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA020790
Pays : United States
Informations de copyright
© 2022. The Author(s).
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