The Role of Acetylcholine on the Effects of Different Doses of Sulfite in Learning and Memory.
Acetylcholine
Hippocampus
Learning
Long term potentiation
Memory
Sulfite
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
11
03
2022
accepted:
11
07
2022
revised:
07
07
2022
pubmed:
28
7
2022
medline:
12
10
2022
entrez:
27
7
2022
Statut:
ppublish
Résumé
In this study, the effects of different doses of sulfite on learning, memory, and long term potentiation as well as the relationship of these effects with acetylcholine pathways, Arc and synapsin 1 levels were investigated. Sixty male Wistar albino rats were randomly divided into three groups as control, S100, and S260. Sodiummetabisulfite (S100;100 mg/kg/day, S260;260 mg/kg/day) was given by oral administration. Behavioral changes were evaluated. After long term potentiation recordings from the perforant pathway-dentate gyrus synapses, animals were sacrificed. Acetylcholinesterase activity, choline acetyltransferase activity, acetylcholine level as well as Arc and Synapsin 1 expressions were analyzed on the hippocampi. The total distance and average velocity values in the open field and Morris water maze tests increased in the sulfite groups, while the discrimination index in the novel object recognition test decreased compared to controls. Acetylcholine levels and choline acetyltransferase activity were also increased in the sulfite groups, while acetylcholinesterase activity was decreased compared to controls. Sulfite intake attenuated long term potentiation in the hippocampus. It has been observed that the excitatory postsynaptic potential slope and population spike amplitude of the field potentials obtained in sulfite groups decreased. This impairment was accompanied by a decrease in Arc and synapsin 1 expressions. In conclusion, it has been shown that sulfite intake in adults impairs learning and memory, possibly mediated by the cholinergic pathway. It is considered that the decrement in Arc and synapsin expressions may play a role in the mechanism underlying the impairment in long term potentiation caused by toxicity.
Identifiants
pubmed: 35895153
doi: 10.1007/s11064-022-03684-z
pii: 10.1007/s11064-022-03684-z
doi:
Substances chimiques
Cholinergic Agents
0
Sulfites
0
Synapsins
0
Choline O-Acetyltransferase
EC 2.3.1.6
Acetylcholinesterase
EC 3.1.1.7
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3331-3343Subventions
Organisme : Akdeniz Üniversitesi
ID : TDK-2018-3762
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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