Micro-fluidic Spray Freeze Dried Ciprofloxacin Hydrochloride-Embedded Dry Powder for Inhalation.
Active pharmaceutical ingredient-embedded dry powder for inhalation (AeDPI)
Adjustable freezing temperature
High fine particle fraction
Porous and brittle microparticle
Spray freeze drying
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
02 Aug 2022
02 Aug 2022
Historique:
received:
04
05
2022
accepted:
15
07
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
4
8
2022
Statut:
epublish
Résumé
Active pharmaceutical ingredient (API)-embedded dry powder for inhalation (AeDPI) is highly desirable for pulmonary delivery of high-dose drug. Herein, a series of spray freeze-dried (SFD) ciprofloxacin hydrochloride (CH)-embedded dry powders were fabricated via a self-designed micro-fluidic spray freeze tower (MFSFT) capable of tuning freezing temperature of cooling air as the refrigerant medium. The effects of total solid content (TSC), mass ratio of CH to
Identifiants
pubmed: 35915199
doi: 10.1208/s12249-022-02371-0
pii: 10.1208/s12249-022-02371-0
doi:
Substances chimiques
Aerosols
0
Powders
0
Ciprofloxacin
5E8K9I0O4U
Leucine
GMW67QNF9C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
211Subventions
Organisme : the Postdoctoral Science Foundation of Jiangsu Province
ID : 2021K356C
Organisme : the Particle Engineering Laboratory at Soochow University
ID : SDHY2136
Organisme : the National Natural Science Foundation of China
ID : 21878197
Organisme : the Natural Science Foundation of Jiangsu Province
ID : BK20180096
Organisme : Jiangsu Higher Education Institutions
ID : 18KJA530004
Organisme : Suzhou Municipal Science and Technology Bureau
ID : SYG201810
Informations de copyright
© 2022. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
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