Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
12 08 2022
12 08 2022
Historique:
received:
19
11
2020
accepted:
08
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
17
8
2022
Statut:
epublish
Résumé
Instrumental learning is driven by a history of outcome success and failure. Here, we examined the impact of serotonin on learning from positive and negative outcomes. Healthy human volunteers were assessed twice, once after acute (single-dose), and once after prolonged (week-long) daily administration of the SSRI citalopram or placebo. Using computational modelling, we show that prolonged boosting of serotonin enhances learning from punishment and reduces learning from reward. This valence-dependent learning asymmetry increases subjects' tendency to avoid actions as a function of cumulative failure without leading to detrimental, or advantageous, outcomes. By contrast, no significant modulation of learning was observed following acute SSRI administration. However, differences between the effects of acute and prolonged administration were not significant. Overall, these findings may help explain how serotonergic agents impact on mood disorders.
Identifiants
pubmed: 35962142
doi: 10.1038/s42003-022-03690-5
pii: 10.1038/s42003-022-03690-5
pmc: PMC9374781
doi:
Substances chimiques
Serotonin Uptake Inhibitors
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
812Subventions
Organisme : Wellcome Trust
ID : 098362/Z/12/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 091593/Z/10/Z
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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