Visualizing "Alternative Isoinformational Engineered" DNA in A- and B-Forms at High Resolution.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
31 08 2022
31 08 2022
Historique:
pubmed:
16
8
2022
medline:
3
9
2022
entrez:
15
8
2022
Statut:
ppublish
Résumé
A fundamental property of DNA built from four informational nucleotide units (GCAT) is its ability to adopt different helical forms within the context of the Watson-Crick pair. Well-characterized examples include A-, B-, and Z-DNA. For this study, we created an isoinformational biomimetic polymer, built (like standard DNA) from four informational "letters", but with the building blocks being artificial. This ALternative Isoinformational ENgineered (ALIEN) DNA was hypothesized to support two nucleobase pairs, the
Identifiants
pubmed: 35969672
doi: 10.1021/jacs.2c05255
doi:
Substances chimiques
DNA, B-Form
0
Nucleotides
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM