Spatial profiling of chromatin accessibility in mouse and human tissues.

Animals Brain / metabolism Cell Differentiation Cell Lineage Chromatin / genetics Chromatin Assembly and Disassembly / genetics Chromatin Immunoprecipitation Sequencing / methods Epigenomics Gene Expression Profiling Genome High-Throughput Nucleotide Sequencing / methods Humans Mice Palatine Tonsil / cytology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 05 08 2021
accepted: 08 07 2022
pubmed: 18 8 2022
medline: 11 9 2022
entrez: 17 8 2022
Statut: ppublish

Résumé

Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context

Identifiants

DOI: 10.1038/s41586-022-05094-1 PMID: 35978191 PMC: PMC9452302
pubmed: 35978191
doi: 10.1038/s41586-022-05094-1
pii: 10.1038/s41586-022-05094-1
pmc: PMC9452302
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

375-383

Subventions

Organisme : NIAMS NIH HHS
ID : R37 AR040072
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH128876
Pays : United States
Organisme : NCI NIH HHS
ID : UG3 CA257393
Pays : United States
Organisme : NCI NIH HHS
ID : UH3 CA257393
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK106857
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG076043
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260507
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA245313
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR002151
Pays : United States
Organisme : European Research Council
ID : 681893
Pays : International

Informations de copyright

© 2022. The Author(s).

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Auteurs

Yanxiang Deng (Y)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-9975-8086

Marek Bartosovic (M)

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Sai Ma (S)

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-9785-7929

Di Zhang (D)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
ORCID: 0000-0001-8466-9868

Petra Kukanja (P)

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1228-5923

Yang Xiao (Y)

Department of Biomedical Engineering, Columbia University, New York, NY, USA.
ORCID: 0000-0001-7878-4923

Graham Su (G)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.

Yang Liu (Y)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.

Xiaoyu Qin (X)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.

Gorazd B Rosoklija (GB)

Department of Psychiatry, Columbia University, New York, NY, USA.
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Macedonian Academy of Sciences & Arts, Skopje, Republic of Macedonia.

Andrew J Dwork (AJ)

Department of Psychiatry, Columbia University, New York, NY, USA.
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Macedonian Academy of Sciences & Arts, Skopje, Republic of Macedonia.
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.

J John Mann (JJ)

Department of Psychiatry, Columbia University, New York, NY, USA.
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Department of Radiology, Columbia University, New York, NY, USA.
ORCID: 0000-0002-0265-6586

Mina L Xu (ML)

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0001-9513-245X

Stephanie Halene (S)

Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-2737-9810

Joseph E Craft (JE)

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-1368-6756

Kam W Leong (KW)

Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.

Maura Boldrini (M)

Department of Psychiatry, Columbia University, New York, NY, USA.
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
ORCID: 0000-0003-3574-7641

Gonçalo Castelo-Branco (G)

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. goncalo.castelo-branco@ki.se.
Ming Wai Lau Centre for Reparative Medicine, Stockholm node, Karolinska Institutet, Stockholm, Sweden. goncalo.castelo-branco@ki.se.
ORCID: 0000-0003-2247-9393

Rong Fan (R)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA. rong.fan@yale.edu.
Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.
Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.
ORCID: 0000-0001-7805-8059

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunoprécipitation › Immunoprécipitation de la chromatine › Séquençage après immunoprécipitation de la chromatine › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Spatial profiling of chromatin accessibility...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Tonsille palatine › Spatial profiling of chromatin accessibility...