pH-Universal Catechol-Amine Chemistry for Versatile Hyaluronic Acid Bioadhesives.


Journal

Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338

Informations de publication

Date de publication:
10 2022
Historique:
revised: 01 07 2022
received: 03 05 2022
pubmed: 22 8 2022
medline: 18 10 2022
entrez: 21 8 2022
Statut: ppublish

Résumé

Catechol, a major mussel-inspired underwater adhesive moiety, has been used to develop functional adhesive hydrogels for biomedical applications. However, oxidative catechol chemistry for interpolymer crosslinking and adhesion is exclusively effective under alkaline conditions, with limited applications in non-alkaline conditions. To overcome this limitation, pH-universal catechol-amine chemistry to recapitulate naturally occurring biochemical events induced by pH variation in the mussel foot is suggested. Aldehyde moieties are introduced to hyaluronic acid (HA) by partial oxidation, which enables dual-mode catechol tethering to the HA via both stable amide and reactive secondary amine bonds. Because of the presence of additional reactive amine groups, the resultant aldehyde-modified HA conjugated with catechol (AH-CA) is effectively crosslinked in acidic and neutral pH conditions. The AH-CA hydrogel exhibits not only fast gelation via active crosslinking regardless of pH conditions, but also strong adhesion and excellent biocompatibility. The hydrogel enables rapid and robust wound sealing and hemostasis in neutral and alkaline conditions. The hydrogel also mediates effective therapeutic stem cell and drug delivery even in dynamic and harsh environments, such as a motile heart and acidic stomach. Therefore, the AH-CA hydrogel can serve as a versatile biomaterial in a wide range of pH conditions in vivo.

Identifiants

pubmed: 35989097
doi: 10.1002/smll.202202729
doi:

Substances chimiques

Aldehydes 0
Amides 0
Biocompatible Materials 0
Catecholamines 0
Catechols 0
Hydrogels 0
Hyaluronic Acid 9004-61-9
catechol LF3AJ089DQ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2202729

Informations de copyright

© 2022 Wiley-VCH GmbH.

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Auteurs

Soohwan An (S)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

Eun Je Jeon (EJ)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
CellArtgen Inc., Seoul, 03722, Republic of Korea.

Seung Yeop Han (SY)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

Jihoon Jeon (J)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

Mi Jeong Lee (MJ)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

Sooyeon Kim (S)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

Mikyung Shin (M)

Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

Seung-Woo Cho (SW)

Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
CellArtgen Inc., Seoul, 03722, Republic of Korea.
Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, 03722, Republic of Korea.
Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, 03722, Republic of Korea.

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Classifications MeSH