Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2.

Cations, Divalent Integrin alphaXbeta2 / chemistry Ligands Protein Binding Protein Structure, Tertiary
CD11c CD18 CP: Molecular biology affinity maturation allostery integrin αX I-domain

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
23 08 2022
Historique:
received: 17 06 2021
revised: 23 05 2022
accepted: 02 08 2022
entrez: 24 8 2022
pubmed: 25 8 2022
medline: 27 8 2022
Statut: ppublish

Résumé

Allosteric activation and silencing of leukocyte β2-integrins transpire through cation-dependent structural changes, which mediate integrin biosynthesis and recycling, and are essential to designing leukocyte-specific drugs. Stepwise addition of Mg

Identifiants

DOI: 10.1016/j.celrep.2022.111254 PMID: 36001965 PMC: PMC9440770
pubmed: 36001965
pii: S2211-1247(22)01072-5
doi: 10.1016/j.celrep.2022.111254
pmc: PMC9440770
mid: NIHMS1832199
pii:
doi:

Substances chimiques

Cations, Divalent 0
Integrin alphaXbeta2 0
Ligands 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111254

Subventions

Organisme : NIGMS NIH HHS
ID : P30 GM133893
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI139651
Pays : United States
Organisme : NIH HHS
ID : S10 OD012331
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Pragya Manandhar (P)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Zahra Mazhar (Z)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Omar Abousaway (O)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Collins Aboagye (C)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Zeinab Moussa (Z)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Daniel Lim (D)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Tannon Yu (T)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

James Byrnes (J)

National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA.

James M Briggs (JM)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Mehmet Sen (M)

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. Electronic address: msen2@cougarnet.uh.edu.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Cations divalents › Heterotropic roles of divalent cations in the...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Intégrine alphaX bêta2 › Heterotropic roles of divalent cations in the...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Heterotropic roles of divalent cations in the...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Heterotropic roles of divalent cations in the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Heterotropic roles of divalent cations in the...