A new solution for UHDP and UHDR (Flash) measurements: Theory and conceptual design of ALLS chamber.

Radiation Dosage Radiometry
FLASH Gas chamber UHDP

Journal

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 28 02 2022
revised: 27 07 2022
accepted: 10 08 2022
pubmed: 29 8 2022
medline: 7 10 2022
entrez: 28 8 2022
Statut: ppublish

Résumé

Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the "FLASH" effect, still pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly improve the accuracy of the radiobiological experiments necessary to fully understand the mechanisms underlying the effect and its dependencies on the beam parameters, and to be able to translate such effect into clinical practice. The standard ionization chamber in UHDP region is significantly affected by the effects of the electric field generated by the enormous density of charges produced by the dose pulse. This work describes the theory and the conceptual design of a gas chamber (the ALLS chamber) which overcomes the above-mentioned problems.

Identifiants

DOI: 10.1016/j.ejmp.2022.08.010 PMID: 36030665
pubmed: 36030665
pii: S1120-1797(22)02034-8
doi: 10.1016/j.ejmp.2022.08.010
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-18

Informations de copyright

Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest F. Galante, G. Mariani, M. Pacitti and G. Felici are SIT employees; G. Felici is a SIT shareholder; A. Gasparini received a grant for a post doc position funded by SIT S.p.A. The remaining authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Fabio Di Martino (F)

Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisa AOUP, ed.18 via Roma 67, Pisa, Italy; Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; INFN, Sezione di Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy. Electronic address: f.dimartino@ao-pisa.toscana.it.

Damiano Del Sarto (D)

Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy.

Maria Giuseppina Bisogni (M)

Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; Department of Physics, University of Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy; INFN, Sezione di Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy.

Simone Capaccioli (S)

Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; Department of Physics, University of Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy.

Federica Galante (F)

SIT S.p.A., via del Commercio 1A, Aprilia (LT), Italy.

Alessia Gasperini (A)

Iridium Kankernetwerk, 2610 Antwerp, Belgium; Antwerp University, Faculty of Medicine and Health Sciences, 2610 Antwerp, Belgium.

Stefania Linsalata (S)

Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisa AOUP, ed.18 via Roma 67, Pisa, Italy.

Giulia Mariani (G)

SIT S.p.A., via del Commercio 1A, Aprilia (LT), Italy.

Matteo Pacitti (M)

SIT S.p.A., via del Commercio 1A, Aprilia (LT), Italy.

Fabiola Paiar (F)

Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; INFN, Sezione di Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy; Radiation Oncology Unit, Department of Translational Research, University of Pisa, Pisa, Italy.

Stefano Ursino (S)

Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; INFN, Sezione di Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy; Radiation Oncology Unit, Department of Translational Research, University of Pisa, Pisa, Italy.

Verdi Vanreusel (V)

Iridium Kankernetwerk, 2610 Antwerp, Belgium; Antwerp University, Faculty of Medicine and Health Sciences, 2610 Antwerp, Belgium.

Dirk Verellen (D)

Iridium Kankernetwerk, 2610 Antwerp, Belgium; Antwerp University, Faculty of Medicine and Health Sciences, 2610 Antwerp, Belgium.

Giuseppe Felici (G)

SIT S.p.A., via del Commercio 1A, Aprilia (LT), Italy.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › A new solution for UHDP and UHDR (Flash)...
questionsmedicales.fr › Techniques d'investigation › Radiométrie › A new solution for UHDP and UHDR (Flash)...