Transition-Linker Containing Detergents for Membrane Protein Studies.


Journal

Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783

Informations de publication

Date de publication:
09 Dec 2022
Historique:
received: 18 07 2022
pubmed: 3 9 2022
medline: 15 12 2022
entrez: 2 9 2022
Statut: ppublish

Résumé

It is a pressing need, but still challenging to explore the structure and function of membrane proteins (MPs). One of the main obstacles is the limited availability of matched detergents for the handling of specific MPs. We describe herein the design of new detergents by incorporation of a transition linker between the hydrophilic head and the hydrophobic tail. This design allows a gradual change of hydrophobicity between the outside and inside of micelles, in contrast to the abrupt switch in conventional detergents. Notably, many of these detergents assembled into micelles in while retaining low critical micelle concentrations. Meanwhile, thermal stabilizing evaluation identified superior detergents for representative MPs, including G protein-coupled receptors and a transporter protein. Among them, further improved the NMR study of MPs. We anticipate these that results will encourage future detergent expansion through new remodeling on the traditional detergent scaffold.

Identifiants

pubmed: 36053145
doi: 10.1002/chem.202202242
doi:

Substances chimiques

Detergents 0
Membrane Proteins 0
Micelles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202202242

Subventions

Organisme : National Natural Science Foundation of China
ID : 21672147

Informations de copyright

© 2022 Wiley-VCH GmbH.

Références

J. P. Overington, B. Al-Lazikani, A. L. Hopkins, Nat. Rev. Drug Discovery 2006, 5, 993-996.
M. S. Almén, K. J. Nordström, R. Fredriksson, H. B. Schiöth, BMC Biol. 2009, 7, 50.
H. M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, P. E. Bourne, Nucleic Acids Res. 2000, 28, 235-242.
B. T. Arachea, Z. Sun, N. Potente, R. Malik, D. Isailovic, R. E. Viola, Protein Expression Purif. 2012, 86, 12-20.
D. Linke, Methods Enzymol. 2009, 463, 603-617.
H. J. Lee, H. S. Lee, T. Youn, B. Byrne, P. S. Chae, Chem 2022, 8, 980-1013.
Y.-C. Lee, J. A. Bååth, R. M. Bastle, S. Bhattacharjee, M. J. Cantoria, M. Dornan, E. Gamero-Estevez, L. Ford, L. Halova, J. Kernan, C. Kürten, S. Li, J. Martinez, N. Sachan, M. Sarr, X. Shan, N. Subramanian, K. Rivera, D. Pappin, S.-H. Lin, J. Proteome Res. 2018, 17, 348-358.
L. Liu, Z. Zhu, F. Zhou, D. Xue, T. Hu, W. Luo, Y. Qiu, D. Wu, F. Zhao, Z. Le, H. Tao, ACS Omega 2021, 6, 21087-21093.
D. Xue, J. Wang, X. Song, W. Wang, T. Hu, L. Ye, Y. Liu, Q. Zhou, F. Zhou, Z. X. Jiang, Z. J. Liu, H. Tao, Langmuir 2019, 35, 4319-4327.
P. Champeil, S. Orlowski, S. Babin, S. Lund, M. le Maire, J. Møller, G. Lenoir, C. Montigny, Anal. Biochem. 2016, 511, 31-35.
A. Anandan, A. Vrielink, Adv. Exp. Med. Biol. 2016, 922, 13-28.
M. Yang, W. Luo, W. Zhang, H. Wang, D. Xue, Y. Wu, S. Zhao, F. Zhao, X. Zheng, H. Tao, Chem. Asian J. 2022, 17, e202200372.
L. Ghani, S. Kim, H. Wang, H. S. Lee, J. S. Mortensen, S. Katsube, Y. Du, A. Sadaf, W. Ahmed, B. Byrne, L. Guan, C. J. Loland, B. K. Kobilka, W. Im, P. S. Chae, Chem. Eur. J. 2022, 28, e202200116.
M. Ehsan, H. Wang, C. Cecchetti, J. S. Mortensen, Y. Du, P. Hariharan, A. Nygaard, H. J. Lee, L. Ghani, L. Guan, C. J. Loland, B. Byrne, B. K. Kobilka, P. S. Chae, ACS Chem. Biol. 2021, 16, 1779-1790.
K. H. Cho, H. E. Bae, M. Das, S. H. Gellman, P. S. Chae, Chem. Asian J. 2014, 9, 632-638.
P. S. Chae, S. G. Rasmussen, R. R. Rana, K. Gotfryd, R. Chandra, M. A. Goren, A. C. Kruse, S. Nurva, C. J. Loland, Y. Pierre, D. Drew, J. L. Popot, D. Picot, B. G. Fox, L. Guan, U. Gether, B. Byrne, B. Kobilka, S. H. Gellman, Nat. Methods 2010, 7, 1003-1008.
S. M. Hickey, T. D. Ashton, G. Boer, C. A. Bader, M. Thomas, A. G. Elliott, C. Schmuck, H. Y. Yu, J. Li, R. L. Nation, M. A. Cooper, S. E. Plush, D. A. Brooks, F. M. Pfeffer, Eur. J. Med. Chem. 2018, 160, 9-22.
J. Cladera, J. L. Rigaud, J. Villaverde, M. Duñach, Eur. J. Biochem. 1997, 243, 798-804.
F. Zhao, Z. Zhu, L. Xie, F. Luo, H. Wang, Y. Qiu, W. Luo, F. Zhou, D. Xue, Z. Zhang, T. Hua, D. Wu, Z.-J. Liu, Z. Le, H. Tao, Chem. Eur. J. 2022, e202201388.
C. Tribet, R. Audebert, J. L. Popot, Proc. Natl. Acad. Sci. USA 1996, 93, 15047-15050.
K. A. Nguyen, M. Peuchmaur, S. Magnard, R. Haudecoeur, C. Boyère, S. Mounien, I. Benammar, V. Zampieri, S. Igonet, V. Chaptal, A. Jawhari, A. Boumendjel, P. Falson, Angew. Chem. Int. Ed. 2018, 57, 2948-2952;
Angew. Chem. 2018, 130, 2998-3002.
A. Stetsenko, A. Guskov, Crystals 2017, 7, 197.
Q. Zhang, V. Cherezov, Curr. Opin. Struct. Biol. 2019, 58, 278-285.
D. T. Murray, J. Griffin, T. A. Cross, Biochemistry 2014, 53, 2454-2463.
G. G. Privé, Curr. Opin. Struct. Biol. 2009, 19, 379-385.
R. M. Garavito, S. Ferguson-Miller, J. Biol. Chem. 2001, 276, 32403-32406.
S. Krimm, J. Polym. Sci. Part B 1980, 18, 687-687.
S. C. Lee, B. C. Bennett, W.-X. Hong, Y. Fu, K. A. Baker, J. Marcoux, C. V. Robinson, A. B. Ward, J. R. Halpert, R. C. Stevens, C. D. Stout, M. J. Yeager, Q. Zhang, Proc. Natl. Acad. Sci. USA 2013, 110, E1203-E1211.
W. X. Hong, K. A. Baker, X. Ma, R. C. Stevens, M. Yeager, Q. Zhang, Langmuir 2010, 26, 8690-8696.
Q. Zhang, H. Tao, W. X. Hong, Methods 2011, 55, 318-323.
Q. Zhang, R. Horst, M. Geralt, X. Ma, W. X. Hong, M. G. Finn, R. C. Stevens, K. Wüthrich, J. Am. Chem. Soc. 2008, 130, 7357-7363.
T. Cheng, Y. Zhao, X. Li, F. Lin, Y. Xu, X. Zhang, Y. Li, R. Wang, L. Lai, J. Chem. Inf. Model. 2007, 47, 2140-2148.
C. A. Bloch, J. B. Watkins, J. Lipid Res. 1978, 19, 510-513.
E. De Vendittis, G. Palumbo, G. Parlato, V. Bocchini, Anal. Biochem. 1981, 115, 278-286.
P. S. Chae, I. A. Guzei, S. H. Gellman, J. Am. Chem. Soc. 2010, 132, 1953-1959.
H. Tao, Y. Fu, A. Thompson, S. C. Lee, N. Mahoney, R. C. Stevens, Q. Zhang, Langmuir 2012, 28, 11173-11181.
S. Lee, S. Ghosh, S. Jana, N. Robertson, C. G. Tate, N. Vaidehi, Biochemistry 2020, 59, 2125-2134.
D. Yang, Q. Zhou, V. Labroska, S. Qin, S. Darbalaei, Y. Wu, E. Yuliantie, L. Xie, H. Tao, J. Cheng, Q. Liu, S. Zhao, W. Shui, Y. Jiang, M. W. Wang, Signal Transduct. Target Ther. 2021, 6, 7.
A. I. Alexandrov, M. Mileni, E. Y. T. Chien, M. A. Hanson, R. C. Stevens, Structure 2008, 16, 351-359.
M. A. Danielson, J. J. Falke, Annu. Rev. Biophys. 1996, 25, 163-195.
D. Rose-Sperling, M. A. Tran, L. M. Lauth, B. Goretzki, U. A. Hellmich, Biol. Chem. 2019, 400, 1277-1288.
J. L. Kitevski-LeBlanc, R. S. Prosser, Prog. Nucl. Magn. Reson. Spectrosc. 2012, 62, 1-33.
H. Ge, H. Wang, B. Pan, D. Feng, C. Guo, L. Yang, D. Liu, K. Wüthrich, Molecules 2022, 27, 2658.
H. Wang, W. Hu, D. Liu, K. Wüthrich, FEBS J. 2021, 288, 4053-4063.
L. Sušac, C. O′Connor, R. C. Stevens, K. Wüthrich, Angew. Chem. Int. Ed. 2015, 54, 15246-15249;
Angew. Chem. 2015, 127, 15461-15464.
L. Sušac, M. T. Eddy, T. Didenko, R. C. Stevens, K. Wüthrich, Proc. Natl. Acad. Sci. USA 2018, 115, 12733-12738.
A. Chattopadhyay, E. London, Anal. Biochem. 1984, 139, 408-412.
W. Liu, E. Chun, A. A. Thompson, P. Chubukov, F. Xu, V. Katritch, G. W. Han, C. B. Roth, L. H. Heitman, I. J. AP, V. Cherezov, R. C. Stevens, Science 2012, 337, 232-236.
X. Li, T. Hua, K. Vemuri, J. H. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, G. W. Han, M. R. Iyer, R. Cinar, N. J. Coffey, J. Wang, M. Wu, V. Katritch, S. Zhao, G. Kunos, L. M. Bohn, A. Makriyannis, R. C. Stevens, Z. J. Liu, Cell 2019, 176, 459-467.e413.
X. Zhang, F. Zhao, Y. Wu, J. Yang, G. W. Han, S. Zhao, A. Ishchenko, L. Ye, X. Lin, K. Ding, V. Dharmarajan, P. R. Griffin, C. Gati, G. Nelson, M. S. Hunter, M. A. Hanson, V. Cherezov, R. C. Stevens, W. Tan, H. Tao, F. Xu, Nat. Commun. 2017, 8, 15383.
A. Ward, C. L. Reyes, J. Yu, C. B. Roth, G. Chang, Proc. Natl. Acad. Sci. USA 2007, 104, 19005-19010.
L. Sušac, M. T. Eddy, T. Didenko, R. C. Stevens, K. Wüthrich, Proc. Natl. Acad. Sci. USA 2018, 115, 12733-12738.
H. Alpes, H. J. Apell, G. Knoll, H. Plattner, R. Riek, Biochim. Biophys. Acta Biomembr. 1988, 946, 379-388.

Auteurs

Weiling Luo (W)

Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, P. R. China.
iHuman Institute, ShanghaiTech University, 201210, Shanghai, P. R. China.
School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, P. R. China.

Meifang Yang (M)

Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, P. R. China.

Yitian Zhao (Y)

Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, P. R. China.

Huixia Wang (H)

iHuman Institute, ShanghaiTech University, 201210, Shanghai, P. R. China.

Xiaodi Yang (X)

Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, P. R. China.

Wei Zhang (W)

College of Chemistry and Materials Science, Hebei Normal University, 050024, Shijiazhuang, P. R. China.

Fei Zhao (F)

iHuman Institute, ShanghaiTech University, 201210, Shanghai, P. R. China.

Suwen Zhao (S)

iHuman Institute, ShanghaiTech University, 201210, Shanghai, P. R. China.
School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, P. R. China.

Houchao Tao (H)

Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, P. R. China.

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Classifications MeSH