Small RNA-Seq Reveals Similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia.
Adolescent
Child
Fibroblast Growth Factor 1
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
Proto-Oncogene Proteins p21(ras)
/ genetics
RNA-Seq
Transcriptome
Young Adult
T-cell acute lymphoblastic leukemia (T-ALL)
adolescents and young adults (AYA)
miR-143-3p
miRNA-seq
pathway analysis
personalized medicine
target prediction
targeting FGFR signaling
tumor suppressor miRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Sep 2022
04 Sep 2022
Historique:
received:
15
07
2022
revised:
21
08
2022
accepted:
30
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
We aimed to identify miRNAs and pathways specifically deregulated in adolescent and young adult (AYA) T-ALL patients. Small RNA-seq showed no major differences between AYA and pediatric T-ALL, but it revealed downregulation of miR-143-3p in T-ALL patients. Prediction algorithms identified several known and putative oncogenes targeted by this miRNA, including
Identifiants
pubmed: 36077521
pii: ijms231710117
doi: 10.3390/ijms231710117
pmc: PMC9456032
pii:
doi:
Substances chimiques
MIRN143 microRNA, human
0
MicroRNAs
0
Fibroblast Growth Factor 1
104781-85-3
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : 2014/15/B/NZ2/03394
Organisme : National Science Center
ID : 2018/02/X/NZ2/01833
Organisme : National Science Center
ID : 2017/25/N/NZ2/01132
Organisme : National Science Center
ID : 2021/41/N/NZ2/02247
Organisme : National Science Center
ID : 2016/23/D/ST7/03665
Organisme : National Centre for Research and Development
ID : STRATEGMED3/304586/5/NCBR/2017
Organisme : European Union's Horizon 2020 research and innovation programme
ID : Grant Agreement No. 952304
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