Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.

Hallucinogens / metabolism Lysergic Acid Diethylamide / chemistry Receptors, Serotonin Serotonin beta-Arrestins / metabolism
Gq protein HTR2B LSD functional selectivity psychedelic signaling transduction structural biology β-arrestin-1

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
05 Oct 2022
Historique:
received: 24 03 2022
revised: 13 07 2022
accepted: 12 08 2022
pubmed: 11 9 2022
medline: 12 10 2022
entrez: 10 9 2022
Statut: ppublish

Résumé

Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs. Although the primary psychedelic drug effects are mediated by the 5-HT

Identifiants

DOI: 10.1016/j.neuron.2022.08.006 PMID: 36087581 PMC: PMC9583076
pubmed: 36087581
pii: S0896-6273(22)00752-8
doi: 10.1016/j.neuron.2022.08.006
pmc: PMC9583076
mid: NIHMS1835617
pii:
doi:

Substances chimiques

Hallucinogens 0
Receptors, Serotonin 0
beta-Arrestins 0
Serotonin 333DO1RDJY
Lysergic Acid Diethylamide 8NA5SWF92O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3154-3167.e7

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM127359
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112205
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA045657
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The Krogan Laboratory has received research support from Vir Biotechnology, F. Hoffmann-La Roche, and Rezo Therapeutics. N.J.K. has financially compensated consulting agreements with the Icahn School of Medicine at Mount Sinai, New York; Maze Therapeutics; Interline Therapeutics; Rezo Therapeutics; GEn1E Life Sciences, Inc.; and Twist Bioscience Corp. N.J.K. is on the Board of Directors of Rezo Therapeutics and is a shareholder in Tenaya Therapeutics, Maze Therapeutics, Rezo Therapeutics, and Interline Therapeutics. G.S. is co-founder and consultant for Deep Apple Therapeutics.

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Auteurs

Can Cao (C)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA.

Ximena Barros-Álvarez (X)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Shicheng Zhang (S)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA.

Kuglae Kim (K)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA.

Marc A Dämgen (MA)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.

Ouliana Panova (O)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Carl-Mikael Suomivuori (CM)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.

Jonathan F Fay (JF)

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 7599-7365, USA.

Xiaofang Zhong (X)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; J. David Gladstone Institutes, San Francisco, CA, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

Brian E Krumm (BE)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA.

Ryan H Gumpper (RH)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA.

Alpay B Seven (AB)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Michael J Robertson (MJ)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Nevan J Krogan (NJ)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; J. David Gladstone Institutes, San Francisco, CA, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

Ruth Hüttenhain (R)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; J. David Gladstone Institutes, San Francisco, CA, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

David E Nichols (DE)

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7365, USA.

Ron O Dror (RO)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA. Electronic address: ron.dror@stanford.edu.

Georgios Skiniotis (G)

Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: yiorgo@stanford.edu.

Bryan L Roth (BL)

Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7365, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7365, USA. Electronic address: bryan_roth@med.unc.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Hallucinogènes › Signaling snapshots of a serotonin receptor...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Ergolines › Acide lysergique › Lysergide › Signaling snapshots of a serotonin receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Signaling snapshots of a serotonin receptor...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Signaling snapshots of a serotonin receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Arrestines › bêta-Arrestines › Signaling snapshots of a serotonin receptor...