Genomics-Guided Efficient Identification of 2,5-Diketopiperazine Derivatives from Actinobacteria.
2,5-DKPs
dimeric DKPs
genome mining
heterologous expression
nucleobase-containing DKPs
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
revised:
12
09
2022
received:
30
08
2022
pubmed:
14
9
2022
medline:
4
2
2023
entrez:
13
9
2022
Statut:
ppublish
Résumé
Secondary metabolites derived from microorganism constitute an important part of natural products. Mining of the microbial genomes revealed a large number of uncharacterized biosynthetic gene clusters, indicating their greater potential to synthetize specialized or secondary metabolites (SMs) than identified by classic fermentation and isolation approaches. Various bioinformatics tools have been developed to analyze and identify such gene clusters, thus accelerating significantly the mining process. Heterologous expression of an individual biosynthetic gene cluster has been proven as an efficient way to activate the genes and identify the encoded metabolites that cannot be detected under normal laboratory cultivation conditions. Herein, we describe a concept of genomics-guided approach by performing genome mining and heterologous expression to uncover novel CDPS-derived DKPs and functionally characterize novel tailoring enzymes embedded in the biosynthetic pathways. Recent works focused on the identification of the nucleobase-related and dimeric DKPs are also presented.
Identifiants
pubmed: 36098493
doi: 10.1002/cbic.202200502
pmc: PMC10092475
doi:
Substances chimiques
2,5-dioxopiperazine
240L69DTV7
Diketopiperazines
0
Biological Products
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200502Informations de copyright
© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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