Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
28 09 2022
Historique:
pubmed: 16 9 2022
medline: 30 9 2022
entrez: 15 9 2022
Statut: ppublish

Résumé

A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic platform to overcome numerous limitations that have plagued this strategically powerful transformation. In its optimized form, coupling partners can be combined in a surprisingly simple way: open to the air, using technical-grade solvents, an inexpensive ligand and Ni source, and substoichiometric AgNO

Identifiants

pubmed: 36106767
doi: 10.1021/jacs.2c08006
pmc: PMC9805175
mid: NIHMS1860989
doi:

Substances chimiques

Esters 0
Ligands 0
Solvents 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

17709-17720

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118176
Pays : United States

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Auteurs

Maximilian D Palkowitz (MD)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Gabriele Laudadio (G)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Simon Kolb (S)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Jin Choi (J)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Martins S Oderinde (MS)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Tamara El-Hayek Ewing (TE)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Philippe N Bolduc (PN)

Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States.

TeYu Chen (T)

Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Hao Zhang (H)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Peter T W Cheng (PTW)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Benxiang Zhang (B)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Michael D Mandler (MD)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Vanna D Blasczak (VD)

Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Jeremy M Richter (JM)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Michael R Collins (MR)

Oncology Medicinal Chemistry Department, Pfizer Pharmaceuticals, 10770 Science Center Drive, San Diego, California 92121, United States.

Ryan L Schioldager (RL)

Oncology Medicinal Chemistry Department, Pfizer Pharmaceuticals, 10770 Science Center Drive, San Diego, California 92121, United States.

Martin Bravo (M)

Oncology Medicinal Chemistry Department, Pfizer Pharmaceuticals, 10770 Science Center Drive, San Diego, California 92121, United States.

T G Murali Dhar (TGM)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Benjamin Vokits (B)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Yeheng Zhu (Y)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Pierre-Georges Echeverria (PG)

Minakem Recherche, 145 Chemin des Lilas, Beuvry-La-Forêt 59310, France.

Michael A Poss (MA)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Scott A Shaw (SA)

Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08534, United States.

Sebastian Clementson (S)

Research and Early Development, LEO Pharma A/S, 2750 Ballerup, Denmark.

Nadia Nasser Petersen (NN)

Research and Early Development, LEO Pharma A/S, 2750 Ballerup, Denmark.

Pavel K Mykhailiuk (PK)

Enamine Ltd., Chervonotkatska 60, 02094 Kyiv, Ukraine.

Phil S Baran (PS)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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Classifications MeSH