Methylglyoxal impairs ATP- and UTP-induced relaxation in the rat carotid arteries.

Acetylcholine / pharmacology Acetylcysteine Adenosine Adenosine Triphosphate / pharmacology Animals Antioxidants / pharmacology Arachidonic Acid Arginine Carotid Arteries Cyclooxygenase Inhibitors Indomethacin / pharmacology Magnesium Oxide Nitric Oxide Polyphosphates Prostaglandin-Endoperoxide Synthases Prostaglandins Pyruvaldehyde / pharmacology Rats Receptors, Purinergic P2Y Sodium Uridine Uridine Triphosphate / pharmacology Vasoconstrictor Agents
Adenosine triphosphate Carotid artery Methylglyoxal Relaxation Uridine triphosphate

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
15 Oct 2022
Historique:
received: 13 05 2022
revised: 09 08 2022
accepted: 05 09 2022
pubmed: 17 9 2022
medline: 7 10 2022
entrez: 16 9 2022
Statut: ppublish

Résumé

Although methylglyoxal (MGO), a highly reactive dicarbonyl compound, influences the functioning of the vasculature, modulating its effects on vascular reactivity to various substances remains unclear, especially purinoceptor ligands. Therefore, we sought to investigate the direct effects of MGO on relaxation induced by adenosine 5'-triphosphate (ATP) and uridine 5'-triphosphate (UTP) in isolated rat carotid arteries. When carotid arteries were exposed to MGO (420 μM for 1 h), relaxation induced by acetylcholine or sodium nitroprusside was not affected by MGO. However, ATP- and UTP-induced relaxation was impaired by MGO compared with the control. In both ATP- and UTP-induced relaxation, endothelial denudation, incubation with the nitric oxide (NO) synthase inhibitor N

Identifiants

DOI: 10.1016/j.ejphar.2022.175259 PMID: 36113554
pubmed: 36113554
pii: S0014-2999(22)00520-9
doi: 10.1016/j.ejphar.2022.175259
pii:
doi:

Substances chimiques

Antioxidants 0
Cyclooxygenase Inhibitors 0
Polyphosphates 0
Prostaglandins 0
Receptors, Purinergic P2Y 0
Vasoconstrictor Agents 0
Arachidonic Acid 27YG812J1I
Nitric Oxide 31C4KY9ESH
Magnesium Oxide 3A3U0GI71G
Pyruvaldehyde 722KLD7415
Adenosine Triphosphate 8L70Q75FXE
Arginine 94ZLA3W45F
Sodium 9NEZ333N27
Prostaglandin-Endoperoxide Synthases EC 1.14.99.1
Adenosine K72T3FS567
Acetylcholine N9YNS0M02X
triphosphoric acid NU43IAG5BC
Uridine Triphosphate UT0S826Z60
Uridine WHI7HQ7H85
Acetylcysteine WYQ7N0BPYC
Indomethacin XXE1CET956

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175259

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest We declare no conflicts of interest.

Auteurs

Takayuki Matsumoto (T)

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan. Electronic address: t-matsu@hoshi.ac.jp.

Miyo Kudo (M)

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan.

Tomoe Osada (T)

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan.

Kumiko Taguchi (K)

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan.

Tsuneo Kobayashi (T)

Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo, 142-8501, Japan. Electronic address: tkoba@hoshi.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Acétylcystéine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras indispensables › Acides arachidoniques › Acide arachidonique › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Arginine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères carotides › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Inhibiteurs des cyclooxygénases › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Indométacine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxyde de magnésium › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Polyphosphates › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Prostaglandin-endoperoxide synthases › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Glyoxal › Méthylglyoxal › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine triphosphate › Methylglyoxal impairs ATP- and UTP-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Vasoconstricteurs › Methylglyoxal impairs ATP- and UTP-induced...